ClpB2 is necessary for the organism and cannot be replenished by mutations in the ClpB1 gene. This cytoplasmic protein is not associated with heat resistance. Giese and Vierling(2002) Changes in oligomerization are critical for chaperone activity of small heat shock proteins in vivo and in vitro. Journal of Biological Chemistry; 277(48): 46310-8.
For research use only, not for clinical use.