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Serine/threonine-protein kinase TOR (TOR), Recombinant Protein
Cat: RP00282
Size: 0.02 mg (E-Coli)/ 0.02 mg (Yeast)/ 0.1 mg (E-Coli)/ 0.1 mg (Yeast)/ 0.02 mg (Baculovirus)/ 0.02 mg (Mammalian-Cell)/ 0.1 mg (Baculovirus)/ 1 mg (E-Coli)/ 1 mg (Yeast)/ 0.1 mg (Mammalian-Cell)/ 1 mg (Baculovirus)/ 0.5 mg (Mammalian-Cell)
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:
Product Info
Full Product Name
Recombinant Arabidopsis thaliana Serine/threonine-protein kinase TOR (TOR) , partial
Product Gene Name
TOR recombinant protein
Product Synonym Gene Name
TOR
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Sequence
APMAAQAAWN MGEWDQMAEY VSRLDDGDET KLRGLASPVS SGDGSSNGTF FRAVLLVRRA KYDEAREYVE RARKCLATEL AALVLESYER AYSNMVRVQQ LSELEEVIEY YTLPVGNTIA EERRALIRNM WTQRIQGSKR NVEVWQALLA VRALVLPPTE DVETWLKFAS LCRKSGRISQ AKSTLLKLLP FDPEVSPENM QYHGPPQVML GYLKYQWSLG EERKRKEAFT KLQILTRELS SVPHSQSDIL ASMVSSKGAN VPLLARVNLK LGTWQWALSS GLNDGSIQEI RDAFDKSTCY APKWAKAWHT WALFNTAVMS HYISRGQIAS QYVVSAVTGY FYSIACAANA KGVDDSLQDI LRLLT
Sequence Positions
1449-1813. Partial
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
279,190 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
Serine/threonine-protein kinase
NCBI/Uniprot Data
NCBI Accession #
NP_175425.2
NCBI GI #
22330143
NCBI GenBank Nucleotide #
NM_103891.4
NCBI GeneID
841427
NCBI Official Full Name
target of rapamycin
NCBI Official Symbol
TOR
NCBI Official Synonym Symbols
F2J10.19; F2J10_19; target of rapamycin
NCBI Protein Information
target of rapamycin
NCBI Summary
Related to TOR proteins from yeast and mammals, regulators of cell growth in response to nutrient availability. TOR proteins belong to the family of phosphatidylinositol 3-kinase and are targets of the antiproliferative drug rapamycin. AtTOR binds the yeast FKBP12 protein in the presence of Rapamycin, is involved in embryogenesis and is expressed in embryos, endosperm and meristems.
UniProt Gene Name
TOR
UniProt Synonym Gene Names
AtTOR
UniProt Protein Name
Serine/threonine-protein kinase TOR
UniProt Synonym Protein Names
Protein TARGET OF RAPAMYCIN
UniProt Primary Accession #
Q9FR53
UniProt Secondary Accession #
Q9LPM4
UniProt Related Accession #
Q9FR53
UniProt Comments
Essential cell growth regulator that controls development from early embryo to seed production. Controls plant growth in environmental stress conditions. Acts through the phosphorylation of downstream effectors that are recruited by the binding partner RAPTOR. Acts by activating transcription, protein synthesis and ribosome biogenesis, and inhibiting mRNA degradation and autophagy. Can phosphorylate TAP46, a regulatory subunit of protein phosphatase 2A that modulates cell growth and survival (PubMed:21216945). Involved in modulating the transition from heterotrophic to photoautotrophic growth by regulating the expression of chloroplast- and photosynthesis-associated genes (PubMed:27479935). Essential for auxin signaling transduction, probably acting in polysomes to maintain the active ATPK1/S6K1 (and thus TIF3H1/eIF3h) phosphorylation status that is critical for translation reinitiation (e.g. uORF-mRNAs loading) (PubMed:23524850, PubMed:27014314). Promotes abscisic acid (ABA) biosynthesis (PubMed:26459592). Involved in the regulation of sugar-mediated (e.g. glucose and sucrose) glycolysis- and mitochondrial bioenergetics-dependent root growth promotion (PubMed:23542588). Required for sugar (e.g. glucose) promotion of hypocotyl elongation in the dark, by activating the brassinosteroid pathway and stabilizing BZR1. The regulation of BZR1 degradation is dependent on autophagy (PubMed:27345161).
For research use only, not for clinical use.