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Serine/threonine-protein kinase Aurora-1 (AUR1), Recombinant Protein
Cat: RP01064
Size: 0.02 mg (E-Coli)/ 0.1 mg (E-Coli)/ 1 mg (E-Coli)/ 5x1 mg (E-Coli)
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:
Product Info
Full Product Name
Recombinant Arabidopsis thaliana Serine/threonine-protein kinase Aurora-1 (AUR1)
Product Synonym Names
Serine/threonine-protein kinase Aurora-1; AtAur1; EC=2.7.11.1; Aurora-like kinase 1
Product Gene Name
AUR1 recombinant protein
Product Synonym Gene Name
AUR1; At4g32830; T16I18.40
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Sequence
MAIPTETQHQ EKEASDASAA AAQKRWTLSD FDIGKPLGRG KFGHVYLARE KRSNHVVALK VLFKSQLQQS QVEHQLRREV EIQSHLRHPN ILRLYGYFYD QKRVYLILEY AARGELYKDL QKCKYFSERR AATYVASLAR ALIYCHGKHV IHRDIKPENL LIGAQGELKI ADFGWSVHTF NRRRTMCGTL DYLPPEMVES VEHDASVDIW SLGILCYEFL YGVPPFEAME HSDTYRRIVQ VDLKFPPKPI ISASAKDLIS QMLVKESSQR LPLHKLLEHP WIVQNADPSG IYRV
Sequence Positions
1-294aa; Full Length
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
54 kDa
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
Serine/threonine-protein kinase
NCBI/Uniprot Data
NCBI Accession #
NP_195009.1
NCBI GI #
15233958
NCBI GenBank Nucleotide #
NM_119436.2
NCBI GeneID
829419
NCBI Official Full Name
serine/threonine-protein kinase aurora-1
NCBI Official Symbol
AUR1
NCBI Official Synonym Symbols
AtAUR1; ataurora1; AUR1; T16I18.40; T16I18_40
NCBI Protein Information
serine/threonine-protein kinase aurora-1
NCBI Summary
Encodes a member of a family of Ser/Thr kinases whose activities peak during cell division. Transcripts are abundant in tissues rich in dividing cells like roots and flowers but are low or absent in fully expanded leaves and stems. In interphase cells, the protein is predominantly nuclear. During mitosis, the protein associates with plant-specific cytoskeletal structures (preprophase band, phragmoplast, nascent cell plate) that are necessary for cytokinesis as well as with the microtubule spindle. It specifically phosphorylates Ser10 of histone H3 and colocalizes with phosphorylated histone H3 during mitosis.
UniProt Gene Name
AUR1
UniProt Synonym Gene Names
AtAur1
UniProt Protein Name
Serine/threonine-protein kinase Aurora-1
UniProt Synonym Protein Names
Aurora-like kinase 1
UniProt Entry Name
AUR1_ARATH
UniProt Primary Accession #
Q9M077
UniProt Secondary Accession #
Q8LBX4
UniProt Related Accession #
Q9M077
UniProt Comments
Phosphorylates specifically 'Ser-10' of histone H3 in vitro and colocalizes with phosphorylated histone H3 during mitosis. Associates with cytoskeletal structures that are necessary for cytokinesis and with the microtubule spindle. Colocalizes also with gamma-tubulin and function in microtubule organizing centers (MTOCs). In contrast with the mammalian B-type Aurora, AUR1 has no kinase activity toward 'Ser-28' of histone H3.
For research use only, not for clinical use.