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Serine/threonine-protein kinase ATR (ATR), Recombinant Protein
Cat: RP00146
Size: 0.5 mg (E-Coli)/ 0.05 mg (Baculovirus)/ 0.5 mg (Yeast)/ 0.05 mg (Mammalian-Cell)/ 1 mg (E-Coli)/ 0.1 mg (Baculovirus)/ 1 mg (Yeast)/ 0.1 mg (Mammalian-Cell)
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:
Product Info
Full Product Name
Recombinant Arabidopsis thaliana Serine/threonine-protein kinase ATR (ATR) , partial
Product Gene Name
ATR recombinant protein
Product Synonym Gene Name
ATR
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Sequence
YPFLCKPKDD LRKDARMMEF TAMINRLLSK YPESRRRKLY IRTFAVAPLT ED CGLVEWVPHT RGLRHILQDI YISCGKFDRQ KTNPQIKRIY DQCAVKKEYE ML KTKILPMFPP VFHKWFLTTF SEPAAWFRSR VAYAHTTAVW SMVGHIVGLG DRHGENILFD STSGDCVHVD FSCLFDKGLQ LEKPELVPFR LTQNMIDGLG IT GYEGIFMRVC EITLTVLRTH RETLMSILET FIHDPLVEWT KSHKSSGVEV QNP HAQRAISSIE ARLQGVVVGV PLPVEGQARR LIADAVSLEN LGKMYIWWMP WF
Sequence Positions
2392-2702aa, Fragment at the C-terminal include PI3K/PI4K domain and FATC domain
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
302,366 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
NCBI/Uniprot Data
NCBI Accession #
NP_001332642.1
NCBI GI #
1063735351
NCBI GenBank Nucleotide #
NM_001344357.1
NCBI GeneID
834082
NCBI Official Full Name
Ataxia telangiectasia-mutated and RAD3-like protein
NCBI Official Symbol
ATR
NCBI Official Synonym Symbols
ARABIDOPSIS THALIANA ATAXIA TELANGIECTASIA-MUTATED AND RAD3-RELATED; ATATR; Ataxia telangiectasia-mutated and RAD3-related; ATRAD3; MHK7.5; MHK7_5
NCBI Protein Information
Ataxia telangiectasia-mutated and RAD3-like protein
NCBI Summary
Encodes a Arabidopsis ortholog of the ATR protein kinase that is involved in a wide range of responses to DNA damage and plays a central role in cell-cycle regulation. Dominant loss of function alleles identified as suppressors of ALS also exhibit increased tolerance to aluminum. This may be due to the inhibition of terminal differentiation of the root apex upon exposure to Al.
UniProt Gene Name
ATR
UniProt Synonym Gene Names
RAD3; AtATR; AtRAD3
UniProt Protein Name
Serine/threonine-protein kinase ATR
UniProt Synonym Protein Names
Ataxia telangiectasia-mutated and Rad3-related homolog; DNA repair protein ATR; Rad3-like protein; AtRAD3
UniProt Primary Accession #
Q9FKS4
UniProt Secondary Accession #
Q9MAZ4
UniProt Related Accession #
Q9FKS4
UniProt Comments
Probable serine/threonine kinase. Plays a central role in cell-cycle regulation by transmitting DNA damage signals to downstream effectors of cell-cycle progression. May recognize the substrate consensus sequence [ST]-Q and phosphorylate histone variant H2AX to form H2AXS139ph at sites of DNA damage, thereby regulating DNA damage response mechanism. Seems to be required for the G2-phase checkpoint in response to replication blocks but not absolutely required in the G2-arrest response to double-strand breaks. May also be involved in the meiosis process. Required for the basal expression of RNR1 (ribonucleotide reductase large subunit). Acts in concert with telomerase to maintain telomeric DNA tracts. Not required for telomere length homeostasis. Required for effective immune responses that involve activation of DNA damage responses (PubMed:24207055).
For research use only, not for clinical use.