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Protein WUSCHEL (WUS), Recombinant Protein
Cat: RP00254
Size: 0.02 mg (E-Coli)/ 0.02 mg (Yeast)/ 0.1 mg (E-Coli)/ 0.1 mg (Yeast)/ 0.02 mg (Baculovirus)/ 0.02 mg (Mammalian-Cell)/ 0.1 mg (Baculovirus)/ 1 mg (E-Coli)/ 1 mg (Yeast)/ 0.1 mg (Mammalian-Cell)/ 1 mg (Baculovirus)/ 0.5 mg (Mammalian-Cell)
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:
Product Info
Full Product Name
Recombinant Arabidopsis thaliana Protein WUSCHEL (WUS)
Product Gene Name
WUS recombinant protein
Product Synonym Gene Name
WUS
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Sequence
MEPPQHQHHH HQADQESGNN NNNKSGSGGY TCRQTSTRWT PTTEQIKILK ELYYNNAIRS PTADQIQKIT ARLRQFGKIE GKNVFYWFQN HKARERQKKR FNGTNMTTPS SSPNSVMMAA NDHYHPLLHH HHGVPMQRPA NSVNVKLNQD HHLYHHNKPY PSFNNGNLNH ASSGTECGVV NASNGYMSSH VYGSMEQDCS MNYNNVGGGW ANMDHHYSSA PYNFFDRAKP LFGLEGHQEE EECGGDAYLE HRRTLPLFPM HGEDHINGGS GAIWKYGQSE VRPCASLELR LN
Sequence Positions
1-292aa; Full-Length
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
33,190 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
Protein
NCBI/Uniprot Data
NCBI Accession #
NP_565429.1
NCBI GI #
18398572
NCBI GenBank Nucleotide #
NM_127349.4
NCBI GeneID
816305
NCBI Official Full Name
Homeodomain-like superfamily protein
NCBI Official Symbol
WUS
NCBI Official Synonym Symbols
PGA6; T27K22.18; T27K22_18; WUS1; WUSCHEL; WUSCHEL 1
NCBI Protein Information
Homeodomain-like superfamily protein
NCBI Summary
Homeobox gene controlling the stem cell pool. Expressed in the stem cell organizing center of meristems. Required to keep the stem cells in an undifferentiated state. Regulation of WUS transcription is a central checkpoint in stem cell control. The size of the WUS expression domain controls the size of the stem cell population through WUS indirectly activating the expression of CLAVATA3 (CLV3) in the stem cells and CLV3 repressing WUS transcription through the CLV1 receptor kinase signaling pathway. Repression of WUS transcription through AGAMOUS (AG) activity controls stem cell activity in the determinate floral meristem. Binds to TAAT element core motif. WUS is also involved in cell differentiation during anther development.
UniProt Gene Name
WUS
UniProt Synonym Gene Names
PGA6; AtWUS
UniProt Protein Name
Protein WUSCHEL
UniProt Synonym Protein Names
Plant growth activator 6
UniProt Primary Accession #
Q9SB92
UniProt Secondary Accession #
Q9SL51
UniProt Related Accession #
Q9SB92
UniProt Comments
Transcription factor that plays a central role during early embryogenesis, oogenesis and flowering, probably by regulating expression of specific genes. Required to specify stem cell identity in meristems, such as shoot apical meristem (SAM). May induce shoot stem cells activity in order to maintain the stem cell identity. Involved in the developmental root meristem. In shoot apices, it is sufficient to induce the expression of CLV3, a putative ligand of the CLV signaling pathway. Also required to sustain organogenesis in the floral meristem by contributing to the expression of its own repressor, the AGAMOUS (AG) gene at the end of flower development. Binds directly to the 5'-TTAAT[GC][GC]-3' DNA sequence in the regulatory sequence of AG and activates its expression directly. Regulates one important step in ovule development to induce integument formation from the underlying chalazal domain. Participates in the promotion of vegetative to embryonic transition. Required to repress LEC1 expression.
For research use only, not for clinical use.