Protein TRANSPORT INHIBITOR RESPONSE 1 (TIR1), Recombinant Protein
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Protein TRANSPORT INHIBITOR RESPONSE 1 (TIR1), Recombinant Protein

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Cat: RP01091
Size: 0.05 mg (E-Coli)/ 0.05 mg (Yeast)/ 0.2 mg (E-Coli)/ 0.5 mg (E-Coli)/ 0.05 mg (Baculovirus)/ 0.2 mg (Yeast)/ 0.5 mg (Yeast)/ 0.05 mg (Mammalian-Cell)/ 1 mg (E-Coli)/ 0.1 mg (Baculovirus)/ 1 mg (Yeast)/ 0.5 mg (Baculovirus)/ 0.1 mg (Mammalian-Cell)/ 1 mg (B
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:

Product Info

Full Product Name
Recombinant Arabidopsis thaliana Protein TRANSPORT INHIBITOR RESPONSE 1 (TIR1) , partial
Product Gene Name
TIR1 recombinant protein
Product Synonym Gene Name
TIR1
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Sequence
MQKRIALSFP EEVLEHVFSF IQLDKDRNSV SLVCKSWYEI ERWCRRKVFI GNCYAVSPAT VIRRFPKVRS VELKGKPHFA DFNLVPDGWG GYVYPWIEAM SSSYTWLEEI RLKRMVVTDD CLELIAKSFK NFKVLVLSSC EGFSTDGLAA IAATCRNLKE LDLRESDVDD VSGHWLSHFP DTYTSLVSLN IS
Sequence Positions
1-192. Fragment at the N-terminal.
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
66,799 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
Protein TRANSPORT INHIBITOR RESPONSE

NCBI/Uniprot Data

NCBI Accession #
NP_567135.1
NCBI GI #
18412567
NCBI GenBank Nucleotide #
NM_116163.4
NCBI GeneID
825473
NCBI Official Full Name
F-box/RNI-like superfamily protein
NCBI Official Symbol
TIR1
NCBI Official Synonym Symbols
AtTIR1; TRANSPORT INHIBITOR RESPONSE 1
NCBI Protein Information
F-box/RNI-like superfamily protein
NCBI Summary
Encodes an auxin receptor that mediates auxin-regulated transcription. It contains leucine-rich repeats and an F-box and interacts with ASK1, ASK2 and AtCUL1 to form SCF-TIR1, an SCF ubiquitin ligase complex. Related to yeast Grr1p and human SKP2 proteins, involved in ubiquitin-mediated processes. Required for normal response to auxin and repressed in response to flagellin. As part of the SCF complex and in the presence of auxin, TIR1 interacts with Aux/IAA transcriptional repressor proteins and mediates their degradation. Mutations in TIR1 block auxin stimulation of flavonoid synthesis.
UniProt Gene Name
TIR1
UniProt Synonym Gene Names
FBL1; WEI1
UniProt Protein Name
Protein TRANSPORT INHIBITOR RESPONSE 1
UniProt Synonym Protein Names
Weak ethylene-insensitive protein 1
UniProt Primary Accession #
Q570C0
UniProt Secondary Accession #
O24660; A5YZP2; B2CVU0
UniProt Related Accession #
Q570C0
UniProt Comments
Auxin receptor that mediates Aux/IAA proteins proteasomal degradation and auxin-regulated transcription. The SCF(TIR1) E3 ubiquitin ligase complex is involved in auxin-mediated signaling pathway that regulate root and hypocotyl growth, lateral root formation, cell elongation, and gravitropism. Appears to allow pericycle cells to overcome G2 arrest prior to lateral root development. Plays a role in ethylene signaling in roots. Confers sensitivity to the virulent bacterial pathogen P.syringae.

For research use only, not for clinical use.