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Protein TOPLESS (TPL), Recombinant Protein
Cat: RP00321
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:
Product Info
Full Product Name
Recombinant Arabidopsis thaliana Protein TOPLESS (TPL) , partial
Product Gene Name
TPL recombinant protein
Product Synonym Gene Name
TPL
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
124,298 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
Protein
NCBI/Uniprot Data
NCBI Accession #
NP_001031050.1
NCBI GI #
79318004
NCBI GenBank Nucleotide #
NM_001035973.3
NCBI GeneID
838144
NCBI Official Full Name
Transducin family protein / WD-40 repeat family protein
NCBI Official Symbol
TPL
NCBI Official Synonym Symbols
F7H2.9; F7H2_9; TOPLESS; WSIP1; WUS-INTERACTING PROTEIN 1
NCBI Protein Information
Transducin family protein / WD-40 repeat family protein
NCBI Summary
Encodes a protein with several WD40 repeats at the C-terminus and predicted protein-protein interaction domains at the N-terminus. Together with the TOPLESS-RELATED PROTEINS (TPRs), it is thought to be involved in transcriptional repression of root-promoting genes in the top half of the embryo during the transition stage of embryogenesis. It can also interact with IAA12 through the EAR domain of IAA12 and the CTLH domain of TPL. The ability of IAA12 to repress transcription is diminished in a tpl-1 mutant background.
UniProt Gene Name
TPL
UniProt Synonym Gene Names
WSIP1
UniProt Protein Name
Protein TOPLESS
UniProt Synonym Protein Names
WUS-interacting protein 1
UniProt Primary Accession #
Q94AI7
UniProt Secondary Accession #
Q9LMQ9
UniProt Related Accession #
Q94AI7
UniProt Comments
Transcriptional corepressor. May repress the expression of root-promoting genes in the top half of the embryo to allow proper differentiation of the shoot pole during the transition stage of embryogenesis. Regulates the expression of PLT1 and PLT2. Negative regulator of jasmonate responses. Negative regulator of auxin responses. Negative regulator of multiple floral organ identity genes (PubMed:23034631). Required for ovule development (PubMed:25378179).
For research use only, not for clinical use.