NCBI Accession #
NP_566423.1
NCBI GenBank Nucleotide #
NM_112075.3
NCBI Official Full Name
Ubiquitin-conjugating enzyme/RWD-like protein
NCBI Official Synonym Symbols
ATELC
NCBI Protein Information
Ubiquitin-conjugating enzyme/RWD-like protein
NCBI Summary
Mutants of this gene were initially identified because of the trichome morphogenesis phenotype. Those trichomes have multiple nuclei, a defect that turns out not to be restricted to the trichomes but also in all endoreduplicating cell types. This gene encodes a ubiquitin-binding protein with sequence similarities with yeast proteins that are components of the ESCRTI-III complexes. The Arabidopsis protein is found associated with the endosome.
UniProt Synonym Gene Names
AtELC
UniProt Protein Name
Protein ELC
UniProt Synonym Protein Names
ESCRT-I complex subunit VPS23 homolog 1
UniProt Primary Accession #
Q9LHG8
UniProt Related Accession #
Q9LHG8
UniProt Comments
Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). May control nuclear division through the microtubule cytoskeleton.