Protein argonaute 6 (AGO6), Recombinant Protein
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Protein argonaute 6 (AGO6), Recombinant Protein

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Cat: RP01567
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:

Product Info

Full Product Name
Recombinant Arabidopsis thaliana Protein argonaute 6 (AGO6) , partial
Product Gene Name
AGO6 recombinant protein
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
98,681 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
Protein argonaute

NCBI/Uniprot Data

NCBI Accession #
NP_180853.2
NCBI GI #
42569579
NCBI GenBank Nucleotide #
NM_128854.4
NCBI GeneID
817856
NCBI Official Full Name
Argonaute family protein
NCBI Official Symbol
AGO6
NCBI Official Synonym Symbols
ARGONAUTE 6; T21L14.12; T21L14_12
NCBI Protein Information
Argonaute family protein
NCBI Summary
Encodes a nuclear localized 879-amino-acid protein that contains conserved PAZ and PIWI domains that is important for the accumulation of specific heterochromatin-related siRNAs, and for DNA methylation and transcriptional gene silencing.
UniProt Gene Name
AGO6
UniProt Protein Name
Protein argonaute 6
UniProt Primary Accession #
O48771
UniProt Related Accession #
O48771
UniProt Comments
Involved in transcriptional gene silencing (TGS). Component of the RISC complex that associate with the small interfering RNA (siRNA) pathway involved in direct cytosine methylation at endogenous DNA repeats. Required for the accumulation of specific siRNAs derived from transgene and heterochromatin-related endogenous loci. Involved in RNA-directed DNA methylation (RdDM) at specific endogenous loci. Probably not required for the accumulation of siRNAs derived from transgene inverted repeats that induce post-transcriptional gene silencing (PTGS). Associates mainly with small RNAs of 24 nucleotide in length and preferentially recruits small RNAs with a 5' terminal adenosine. Targeted by turnip yellows virus (TuYV) protein P0 (via F-box-like domain) for probable proteasome degradation and thereby inactivating AGO6 function in RNA silencing.

For research use only, not for clinical use.