Plant Protein-Nucleic Acid Interaction Verification Services

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Plant Protein-Nucleic Acid Interaction Verification Services

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Plant Protein-Nucleic Acid Interaction Verification Services.

CD BioSciences provides validation services on plant protein-nucleic acid interactions. We have advanced equipment and technology to help clients explore the mechanism of plant proteins in the process of gene replication, transcription, translation, and modification.

Service Content

Our technologies Descriptions
Electrophoretic mobility shift assay (EMSA) service Our EMSA service is used for in vitro detection of specific DNA binding proteins in crude protein extracts. In addition, we offer capillary gel block electrophoresis, which does not require radioisotopes, low sample volume, and high resolution.
Yeast three-hybrid (Y3H) service We offer Y3H services to analyze plant protein-RNA interactions. Our service is capable of resolving advanced RNA-protein complexes.
Plant protein and DNA/RNA co-localization (IF-FISH) service Our IF-FISH service enables the co-localization of nucleic acids and plant proteins in cells and describes the presence of nucleic acid-protein interactions from a co-localization perspective.
Nitrocellulose membrane (NCF) filtration assay service We use the fact that proteins bind to NCF, but DNA does not, to determine the extent of protein-DNA binding by quantitatively analyzing the complexes left on the filter membrane by markers.
Southwestern blot service We offer the southwestern blot for qualitative and quantitative analysis of DNA binding proteins by radioautography.
Chromatin immunoprecipitation (ChIP) service Our ChIP technology investigates protein-DNA interactions in vivo, does not require extraction of nucleic acids or proteins, and maintains the true binding state in cells.
Dual luciferase reporter gene assay service Our dual luciferase reporter gene assay service can sensitively detect gene expression and assay transcription factors interacting with DNA in the promoter region of the target gene.

Application Fields

The research of plant protein-nucleic acid interactions has multiple areas of application in plant biology research, including

  • Unraveling gene regulatory mechanisms and identifying transcription factors, chromatin modifiers, and other regulatory proteins that control gene expression.
  • Understand RNA processing, selective splicing, RNA stability, and translational regulation.
  • Understand the molecular mechanisms by which proteins recognize and bind to specific DNA or RNA sequences in response to environmental cues or pathogen invasion, and unravel the molecular mechanisms of plant immune and stress signaling pathways.
  • Develop molecular tools for targeted gene expression and genome editing technologies.
  • Conserved nucleic acid binding domains can serve as potential drug targets and thus may provide new avenues for drug discovery.

CD BioSciences is committed to providing cutting-edge plant protein-nucleic acid interaction validation services, providing insights into fundamental plant biological processes, and developing new strategies to improve crop productivity and address agricultural challenges. If you are interested in our services, please contact us for more information.

Reference

  1. Ferraz, R. A. C., et al. (2021). DNA-protein interaction studies: a historical and comparative analysis. Plant methods. 17(1), 82.

For research use only, not for clinical use.