NCBI Accession #
NP_200250.1
NCBI GenBank Nucleotide #
NM_124819.3
NCBI Official Full Name
HAL2-like protein
NCBI Official Synonym Symbols
AHL; ATAHL; F24B18.1; F24B18_1; HAL2-like
NCBI Protein Information
HAL2-like protein
NCBI Summary
Encodes a 3'-phosphoadenosine-5'-phosphate (PAP) phosphatase that is sensitive to physiological concentrations of Na+. It does not also act as inositol polyphosphate 1-phosphatases, which other members of the HAL2-like family do. It is proposed that AHL acts in concert with sulphotransferases to prevent both the toxicity of PAP on RNA processing enzymes as well as the product inhibition of PAP on sulphate conjugation.
UniProt Protein Name
PAP-specific phosphatase HAL2-like
UniProt Synonym Protein Names
3'(2'),5'-bisphosphate nucleotidase (EC:3.1.3.7); 3'(2'),5-bisphosphonucleoside 3'(2')-phosphohydrolase; DPNPase; Halotolerance protein
UniProt Primary Accession #
Q38945
UniProt Secondary Accession #
O48892
UniProt Related Accession #
Q38945
UniProt Comments
Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. May regulate the flux of sulfur in the sulfur-activation pathway by converting PAPS to APS . Prevents both the toxicity of PAP on RNA processing enzymes as well as the product inhibition by PAP of sulfate conjugation.