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Obtusifoliol 14-alpha demethylase (CYP51), Recombinant Protein
Cat: RP19928
Species: Sorghum bicolor (Sorghum) (Sorghum vulgare)
Datasheet:
Product Info
Full Product Name
Recombinant Sorghum bicolor Obtusifoliol 14-alpha demethylase (CYP51)
Product Synonym Names
Recombinant Obtusifoliol 14-alpha demethylase (CYP51); Obtusifoliol 14-alpha demethylase EC= 1.14.13.70; CYPLI Cytochrome P450 51 Cytochrome P450-LIA1
Product Gene Name
CYP51 recombinant protein
Product Synonym Gene Name
CYP51
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Sequence
MDLADIPQQQ RLMAGLALVV ATVIFLKLLL SFRSGGGKKR LPPTIPGAPV VGGLVKFMRG PIPMIREQYA ALGSVFTVPI ITRRITFLIG PEVSAHFFKG NEAEMSQQEV YRFNVPTFGP GVVFDVDYSV RQEQFRFFTE ALRANKLRSY VDQMVAEAEE YFSKWGESGT VDLKYELEHL IILTASRCLL GREVREKLFD DVSALFHDLD NGIQPISVLF PYLPIPAHKR RDKARARLAE IFATIIKSRK ASGQSEEDML QCFIDSKYKN GRPTTEGEVT GLLIAALFAG QHTSSITSTW TGAYMLRFKQ YFAEAVEEQK DVMKRHGDKI DHDILAEMDV LYRCIKEALR LHPPLIMLLR QSHSDFTVTT KEGKEYDIPK GHIVATSPSF ANRLPHIYKN PDSYDPDRFG PGREEDKAAG AFSYISFGGG RHGCLGEPFA YLQIKAIWTH LLRNFEFELV SPFPENDWNA MVVGIKGEVM VNYKRRKLVV DN
Sequence Positions
1-492
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
55,653 Da
Storage
Store at -20℃. For extended storage, store at -20 or -80℃.
Protein Family
Obtusifoliol 14-alpha demethylase
NCBI/Uniprot Data
NCBI Accession #
P93846.1
NCBI GI #
5921924
NCBI Official Full Name
Obtusifoliol 14-alpha demethylase
UniProt Gene Name
CYP51
UniProt Protein Name
Obtusifoliol 14-alpha demethylase
UniProt Synonym Protein Names
CYPLI; Cytochrome P450 51; Cytochrome P450-LIA1
UniProt Entry Name
CP51_SORBI
UniProt Primary Accession #
P93846
UniProt Comments
Function: Catalyzes the 14-alpha demethylation of obtusifoliol to 4 alpha-methyl-5 alpha-ergosta-8,14,24(28)-trien-3 beta-ol.
Catalytic activity: Obtusifoliol + 3 O2 + 3 NADPH = 4-alpha-methyl-5-alpha-ergosta-8,14,24(28)-trien-3-beta-ol + formate + 3 NADP+ + 4 H2O.
Cofactor: Heme group.
Pathway: Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 1/6.
Subcellular location: Membrane
Potential. Membrane; Single-pass membrane protein.
Sequence similarities: Belongs to the cytochrome P450 family.
Catalytic activity: Obtusifoliol + 3 O2 + 3 NADPH = 4-alpha-methyl-5-alpha-ergosta-8,14,24(28)-trien-3-beta-ol + formate + 3 NADP+ + 4 H2O.
Cofactor: Heme group.
Pathway: Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 1/6.
Subcellular location: Membrane
Potential. Membrane; Single-pass membrane protein.
Sequence similarities: Belongs to the cytochrome P450 family.
For research use only, not for clinical use.