NCBI Accession #
NP_563882.1
NCBI GenBank Nucleotide #
NM_100975.2
NCBI Official Full Name
MLO-like protein 4
NCBI Official Symbol
MLO4
NCBI Official Synonym Symbols
ATMLO4; MILDEW RESISTANCE LOCUS O 4; MLO4; T19D16.26; T19D16_26
NCBI Protein Information
MLO-like protein 4
NCBI Summary
A member of a large family of seven-transmembrane domain proteins specific to plants, homologs of the barley mildew resistance locus o (MLO) protein. The Arabidopsis genome contains 15 genes encoding MLO proteins, with localization in plasma membrane. Phylogenetic analysis revealed four clades of closely-related AtMLO genes. ATMLO4 belongs to the clade I, with AtMLO11 and AtMLO14. The gene is expressed during early seedling growth, in roots and lateral root primordia, in flower and fruit abscission zone, in vascular system of root, cotyledons and young leaves, it was not expressed in mature rosette leaves, as shown by GUS activity patterns. The expression of several phylogenetically closely-related AtMLO genes showed similar or overlapping tissue specificity and analogous responsiveness to external stimuli, suggesting functional redundancy, co-function, or antagonistic function(s).
UniProt Synonym Gene Names
AtMlo4
UniProt Protein Name
MLO-like protein 4
UniProt Entry Name
MLO4_ARATH
UniProt Primary Accession #
O23693
UniProt Secondary Accession #
Q94KB8
UniProt Related Accession #
O23693
UniProt Comments
Function: May be involved in modulation of pathogen defense and leaf cell death. Activity seems to be regulated by Ca2+-dependent calmodulin binding and seems not to require heterotrimeric G proteins By similarity.Subcellular location: Membrane; Multi-pass membrane protein By similarity. Domain: The C-terminus contains a calmodulin-binding domain, which binds calmodulin in a calcium-dependent fashion By similarity.Sequence similarities: Belongs to the MLO family.Sequence caution: The sequence AAB65495.1 differs from that shown. Reason: Erroneous gene model prediction.