Mitogen-activated protein kinase kinase 4 (MKK4), Recombinant Protein
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Mitogen-activated protein kinase kinase 4 (MKK4), Recombinant Protein

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Cat: RP01179
Size: 0.02 mg (E-Coli)/ 0.02 mg (Yeast)/ 0.1 mg (E-Coli)/ 0.1 mg (Yeast)/ 0.02 mg (Baculovirus)/ 0.02 mg (Mammalian-Cell)/ 0.1 mg (Baculovirus)/ 1 mg (E-Coli)/ 1 mg (Yeast)/ 0.1 mg (Mammalian-Cell)/ 1 mg (Baculovirus)/ 0.5 mg (Mammalian-Cell)
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:

Product Info

Full Product Name
Recombinant Arabidopsis thaliana Mitogen-activated protein kinase kinase 4 (MKK4)
Product Gene Name
MKK4 recombinant protein
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Sequence
MRPIQSPPGV SVPVKSRPRR RPDLTLPLPQ RDVSLAVPLP LPPTSGGSGG SSGSAPSSGG SASSTNTNSS IEAKNYSDLV RGNRIGSGAG GTVYKVIHRP SSRLYALKVI YGNHEETVRR QICREIEILR DVNHPNVVKC HEMFDQNGEI QVLLEFMDKG SLEGAHVWKE QQLADLSRQI LSGLAYLHSR HIVHRDIKPS NLLINSAKNV KIADFGVSRI LAQTMDPCNS SVGTIAYMSP ERINTDLNQG KYDGYAGDIW SLGVSILEFY LGRFPFPVSR QGDWASLMCA ICMSQPPEAP ATASPEFRHF ISCCLQREPG KRRSAMQLLQ HPFILRASPS QNRSPQNLHQ LLPPPRPLSS SSSPTT
Sequence Positions
1-366, Full length protein
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
40,117 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
Mitogen-activated protein kinase kinase

NCBI/Uniprot Data

NCBI Accession #
NP_175577.1
NCBI GI #
15217998
NCBI GenBank Nucleotide #
NM_104044.3
NCBI GeneID
841591
NCBI Official Full Name
mitogen-activated protein kinase kinase 4
NCBI Official Symbol
MKK4
NCBI Official Synonym Symbols
ARABIDOPSIS THALIANA MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4; ATMEK4; ATMKK4; F19C24.26; F19C24_26; MAP KINASE KINASE 4; mitogen-activated protein kinase kinase 4
NCBI Protein Information
mitogen-activated protein kinase kinase 4
NCBI Summary
Encodes a mitogen-activated map kinase kinase (there are nine in Arabidopsis) involved in innate immunity. This protein activates MPK3/MPK6 and early-defense genes redundantly with MKK5. In plants with both MKK5 and MKK6 levels reduced by RNAi plants, floral organs do not abscise suggestion a role for both proteins in mediating floral organ abscission.
UniProt Gene Name
MKK4
UniProt Synonym Gene Names
AtMKK4; MAP kinase kinase 4
UniProt Protein Name
Mitogen-activated protein kinase kinase 4
UniProt Primary Accession #
O80397
UniProt Related Accession #
O80397
UniProt Comments
Involved in the second phase of hydrogen peroxide generation during hypersensitive response-like cell death. Involved in the innate immune MAP kinase signaling cascade (MEKK1, MKK4/MKK5 and MPK3/MPK6) downstream of bacterial flagellin receptor FLS2. Activates by phosphorylation the downstream MPK3 and MPK6. YDA-MKK4/MKK5-MPK3/MPK6 module regulates stomatal cell fate before the guard mother cell (GMC) is specified. This MAPK cascade also functions downstream of the ER receptor in regulating coordinated local cell proliferation, which shapes the morphology of plant organs. MKK4 and MKK5 participate in the regulation of floral organ abscission. Mediates osmotic-stress response via its regulation of MPK3 activity. Target of the Pseudomonas syringae type III effector HopF2.

For research use only, not for clinical use.