NCBI Accession #
NP_567950.1
NCBI GenBank Nucleotide #
NM_119564.5
NCBI Official Full Name
3-methylcrotonyl-CoA carboxylase
NCBI Official Symbol
MCCB
NCBI Official Synonym Symbols
3-methylcrotonyl-CoA carboxylase; 3-METHYLCROTONYL-COA CARBOXYLASE; F28A23.210; F28A23_210
NCBI Protein Information
3-methylcrotonyl-CoA carboxylase
NCBI Summary
MCC-B is involved in leucine degradation in mitochondria. The active protein is a dimer of MCC-A and MCC-B. MCC-A is biotinylated whereas MCC-B is not.
UniProt Synonym Gene Names
MCCase subunit beta
UniProt Protein Name
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial
UniProt Synonym Protein Names
3-methylcrotonyl-CoA carboxylase 2; 3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta
UniProt Primary Accession #
Q9LDD8
UniProt Secondary Accession #
O49501; Q94F35
UniProt Related Accession #
Q9LDD8
UniProt Comments
Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism.