NCBI Accession #
NP_171719.2
NCBI GenBank Nucleotide #
NM_100097.5
NCBI Official Full Name
metacaspase 1
NCBI Official Synonym Symbols
ARABIDOPSIS THALIANA METACASPASE 1; ARABIDOPSIS THALIANA METACASPASE 1B; ATMC1; AtMCP1b; ATMCPB1; LOL3; LSD ONE LIKE 3; MCP1b; MCP1B; metacaspase 1; metacaspase 1b; T6A9.24
NCBI Protein Information
metacaspase 1
NCBI Summary
Encodes a type I metacaspase. Two Arabidopsis metacaspases, AT1G02170 (MC1) and AT4G25110 (MC2) antagonistically control programmed cell death in Arabidopsis. MC1 is a positive regulator of cell death and requires conserved caspase-like putative catalytic residues for its function. MC2 negatively regulates cell death. This function is independent of the putative catalytic residues. A third type I Arabidopsis metacaspase is MC3 (AT5g64240).
UniProt Synonym Gene Names
LOL3; MCP1B; AtMC1; AtMCP1b
UniProt Protein Name
Metacaspase-1
UniProt Synonym Protein Names
Metacaspase 1b; AtMCP1b; Protein LSD ONE LIKE 3
UniProt Primary Accession #
Q7XJE6
UniProt Secondary Accession #
O81911
UniProt Related Accession #
Q7XJE6
UniProt Comments
Cysteine protease that cleaves specifically after arginine or lysine residues. Does not cleave caspase-specific substrates. Acts as a positive regulator of cell death. Required for both oxidative stress cell death response and hypersensitive cell death response mediated by immune response.