NCBI Accession #
NP_564307.1
NCBI GenBank Nucleotide #
NM_102605.3
NCBI Official Full Name
MAC/Perforin domain-containing protein
NCBI Official Symbol
NSL1
NCBI Official Synonym Symbols
F3M18.18; F3M18_18; necrotic spotted lesions 1
NCBI Protein Information
MAC/Perforin domain-containing protein
NCBI Summary
This gene is predicted to encode a protein involved in negatively regulating salicylic acid-related defense responses and cell death programs. nsl1 mutants develop necrotic lesions spontaneously and show other features of a defense response, such as higher levels of SA and disease resistance-related transcripts, in the absence of a biotic stimulus. The NSL1 protein is predicted to have a MACPF domain, found in proteins that form a transmembrane pore in mammalian immune responses. NSL1 transcript levels do not appear to change in response to biotic stresses, but are elevated by cycloheximide in seedlings, and by sodium chloride in roots.
UniProt Synonym Gene Names
Protein NSL1
UniProt Protein Name
MACPF domain-containing protein NSL1
UniProt Synonym Protein Names
Protein NECROTIC SPOTTED LESIONS 1; Protein NSL1
UniProt Primary Accession #
Q9SGN6
UniProt Related Accession #
Q9SGN6
UniProt Comments
Negatively controls the salicylic acid (SA)-mediated pathway of programmed cell death in plant immunity.