NCBI Accession #
NP_001325682.1
NCBI GenBank Nucleotide #
NM_001339683.1
NCBI Official Full Name
histone H2A 11
NCBI Official Symbol
HTA11
NCBI Official Synonym Symbols
histone H2A 11
NCBI Protein Information
histone H2A 11
NCBI Summary
Encodes HTA11, a histone H2A protein. Loss of all H2A.Z (triple mutant with HTA8 and HTA9) results in a reduction in DNA methylation of transposons but not that of genes. Loss of H2A.Z causes misregulation of many genes involved in the response to developmental and environmental cues, and that these genes tend to have high levels of gene-body H2A.Z.
UniProt Protein Name
Histone H2A variant 1
UniProt Synonym Protein Names
H2A.F/Z 1; H2AvAt; HTA11
UniProt Primary Accession #
O23628
UniProt Related Accession #
O23628
UniProt Comments
Variant histone H2A which may replace conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling .