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Helicase protein MOM1 (MOM1), Recombinant Protein
Cat: RP01988
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:
Product Info
Full Product Name
Recombinant Arabidopsis thaliana Helicase protein MOM1 (MOM1) , partial
Product Gene Name
MOM1 recombinant protein
Product Synonym Gene Name
MOM1
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
218,569 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
Helicase protein
NCBI/Uniprot Data
NCBI Accession #
NP_563806.1
NCBI GI #
18390848
NCBI GenBank Nucleotide #
NM_100680.4
NCBI GeneID
837322
NCBI Official Full Name
ATP-dependent helicase family protein
NCBI Official Symbol
MOM
NCBI Official Synonym Symbols
MAINTENANCE OF METHYLATION; MOM1; MORPHEUS MOLECULE; MORPHEUS MOLECULE 1; T6D22.14; T6D22_14
NCBI Protein Information
ATP-dependent helicase family protein
NCBI Summary
Encodes a transcriptional silencer.
UniProt Gene Name
MOM1
UniProt Synonym Gene Names
MOM
UniProt Protein Name
Helicase protein MOM1
UniProt Synonym Protein Names
Protein MAINTENANCE OF METHYLATION; Protein MORPHEUS MOLECULE 1
UniProt Primary Accession #
Q9M658
UniProt Secondary Accession #
Q8GXZ0; Q9LN02; Q9M659
UniProt Related Accession #
Q9M658
UniProt Comments
Required for the heritable maintenance of transcriptional gene silencing (TGS) in heterochromatin, and particularly in the intermediate bivalent heterochromatin, characterized by an unsual methylation pattern consisting in hypermethylated DNA and histone H3 'Lys-4' methylation (H3K4me) together with depletion of histone H3 'Lys-9' methylation (H3K9me), in a chromatin methylation-independent manner, in a non-CG methylation context. May play a role in the RNA polymerase IV/V (Pol-IV/V)-mediated RNA-directed DNA methylation (RdDM) leading to TGS (also called siRNA-mediated TGS pathway), probably by modulating small interfering RNA (siRNA) accumulation. Especially involved in the gene silencing of the transcriptionally silent information region (TSI), 5S ribosomal RNA genes (localized in the pericentromeric heterochromatin of chromosomes 3, 4, and 5) and of 180-bp satellite repeats and 106B long terminal repeat (LTR)-like repeats of the chromocenters. Prevents the aberrant mRNA transcriptional read-through.
For research use only, not for clinical use.