H3R2me2(sym)K4me2 | Histone H3 (sym-dimethylated Arg2, dimethyl Lys4)

This antibody preparation is provided in 20 mM Potassium Phosphate pH 7,2, 150 mM NaCl, 0,01% sodium azide and 30% glycerol

Common histone modifications include methylation of lysine and arginine, acetylation of lysine, phosphorylation of threonine and serine, threonylation of lysine, biotinylation, and ubiquitination. The dimethylation of H3's arginine 2 (H3R2me2) and lysine 4 (H3K4me2) are both known markers with opposite effects. R2me2 maintains transcriptional silence by silencing SET1-mediated K4 methylation, which is typically associated with active chromatin. The protein arginine methyltransferase PRMT6 can methylate H3K4 in vivo, and overexpression of this enzyme down-regulates Hox and MYC-dependent genes, both of which are targets for H3K4 methylation.