H3R17me2(asym) | Histone H3 (asym-dimethyl Arg17)

This antibody preparation is provided in 20 mM Potassium Phosphate pH 7,2, 150 mM NaCl, 0,01% sodium azide and 30% glycerol

Common histone modifications include methylation of lysine and arginine, acetylation of lysine, phosphorylation of threonine and serine, threonylation of lysine, biotinylation, and ubiquitination. In particular, dimethylation of H3 Arg17 (H3 R17Me2) is associated with gene activation. Coactivator-associated arginine methyltransferase-1 (CARM1) catalyzes the core methylation of Arg17 through its protein arginine methyltransferase (PRMT). Activation of this modification is related to transcriptional hormone response promoters and cell fate regulation. Interestingly, H3 methylation of R17 and R26 contributes to the greater pluripotent potential of stem cells, and this downregulation of PTM increases differentiation.