Flap endonuclease 1-A (FEN1-A), Recombinant Protein
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Flap endonuclease 1-A (FEN1-A), Recombinant Protein

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Cat: RP20127
Size: 0.02 mg (E-Coli)/ 0.02 mg (Yeast)/ 0.1 mg (E-Coli)/ 0.1 mg (Yeast)/ 0.02 mg (Baculovirus)/ 0.02 mg (Mammalian-Cell)/ 0.1 mg (Baculovirus)/ 1 mg (E-Coli)/ 1 mg (Yeast)/ 0.1 mg (Mammalian-Cell)/ 1 mg (Baculovirus)/ 0.5 mg (Mammalian-Cell)
Species: Sorghum bicolor (Sorghum) (Sorghum vulgare)
Datasheet:

Product Info

Full Product Name
Recombinant Sorghum bicolor Flap endonuclease 1-A (FEN1-A)
Product Gene Name
FEN1-A recombinant protein
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Sequence
MGIKGLTKLL ADNAPKAMKE QKFESYFGRK IAIDASMSIY QFLIVVGRTG METLTNEAGE VTSHLQGMFN RTIRLLEAGI KPVYVFDGKP PDMKKEELAK RFSKREDATN DLKEAVEAGD KDAVEKLSKR TVKVTAQHND DCKRLLRLMG VPVVEAPSEA EAECAALCKN DKVFAVASED MDSLTFGAPR FLRHLMDPSS KKIPVMEFDV AKVLEELELT MDQFIDLCIL CGCDYCDSIK GIGGQTALKL IRQHGSIESI LENLNKDRYQ IPEDWPYQEA RRLFKEPNVT LDVPELKWTP PDEEGLISFL VKDNGFNEDR VTKAIEKIKS AKNKSSQGRL ESFFKPVATT SAPLKRKETS DKTSKAAAAN KKTKAGGKKK
Sequence Positions
1-380, Full length protein
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
42,403 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
Flap endonuclease

NCBI/Uniprot Data

NCBI Accession #
XP_002441450.1
NCBI GI #
242091235
NCBI GenBank Nucleotide #
XM_002441405.2
NCBI GeneID
8061074
NCBI Official Full Name
flap endonuclease 1-A
NCBI Official Symbol
LOC8061074  
NCBI Official Synonym Symbols
FEN1-A; FEN-1-A  
NCBI Protein Information
flap endonuclease 1-A
UniProt Gene Name
FEN1-A  
UniProt Synonym Gene Names
FEN-1-A  
UniProt Protein Name
Flap endonuclease 1-A
UniProt Synonym Protein Names
Flap structure-specific endonuclease 1-A
UniProt Primary Accession #
C5YUK3
UniProt Related Accession #
C5YUK3
UniProt Comments
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.

For research use only, not for clinical use.