Flap endonuclease 1-A (FEN-1a), Recombinant Protein
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Flap endonuclease 1-A (FEN-1a), Recombinant Protein

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Cat: RP13169
Size: 0.02 mg (E-Coli)/ 0.02 mg (Yeast)/ 0.1 mg (E-Coli)/ 0.1 mg (Yeast)/ 0.02 mg (Baculovirus)/ 0.02 mg (Mammalian-Cell)/ 0.1 mg (Baculovirus)/ 1 mg (E-Coli)/ 1 mg (Yeast)/ 0.1 mg (Mammalian-Cell)/ 1 mg (Baculovirus)/ 0.5 mg (Mammalian-Cell)
Species: Oryza sativa subsp. japonica (Rice)
Datasheet:

Product Info

Full Product Name
Recombinant Oryza sativa subsp. japonica Flap endonuclease 1-A (FEN-1a)
Product Gene Name
FEN-1a recombinant protein
Product Synonym Gene Name
FEN-1a
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Sequence
MGIKGLTKLL ADNAPKAMKE QKFESYFGRR IAVDASMSIY QFLIVVGRTG METLTNEAGE VTSHLQGMFN RTIRLLEAGI KPVYVFDGKP PDLKKQELAK RYSKREDATK ELTEAVEEGD KDAIEKFSKR TVKVTKQHNE ECKRLLRLMG VPVVEAPCEA EAECAALCIN DMVYAVASED MDSLTFGAPR FLRHLMDPSS KKIPVMEFEV AKVLEELELT MDQFIDLCIL SGCDYCDSIK GIGGQTALKL IRQHGSIESI LENINKDRYQ IPEDWPYQEA RRLFKEPNVT LDIPELKWNA PDEEGLVEFL VKENGFNQDR VTKAIEKIKF AKNKSSQGRL ESFFKPVVST SVPLKRKDTS EKPTKAVANK KTKGAGGKKK
Sequence Positions
1-380, Full length protein
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
42,792 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.

NCBI/Uniprot Data

NCBI Accession #
XP_015639321.1
NCBI GI #
1002269954
NCBI GenBank Nucleotide #
XM_015783835.1
NCBI GeneID
4339464
NCBI Official Full Name
flap endonuclease 1-A
NCBI Official Symbol
LOC4339464
NCBI Official Synonym Symbols
FEN-1; FEN-1a; FEN-1-A; OsFEN-1a; OsJ_19381
NCBI Protein Information
flap endonuclease 1-A
UniProt Gene Name
FEN1A
UniProt Synonym Gene Names
FEN-1-A
UniProt Protein Name
Flap endonuclease 1-A
UniProt Synonym Protein Names
Flap structure-specific endonuclease 1-A
UniProt Primary Accession #
Q9SXQ6
UniProt Secondary Accession #
Q0DGD0; Q53WJ9; A0A0P0WQE5
UniProt Related Accession #
Q9SXQ6
UniProt Comments
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA . May be required for cell proliferation.

For research use only, not for clinical use.