NCBI Accession #
XP_015637672.1
NCBI GenBank Nucleotide #
XM_015782186.1
NCBI Official Full Name
FACT complex subunit SSRP1-B
NCBI Official Symbol
LOC4337994
NCBI Official Synonym Symbols
SSRP1-B; P0683B12.1
NCBI Protein Information
FACT complex subunit SSRP1-B
UniProt Gene Name
SSRP1-B
UniProt Protein Name
FACT complex subunit SSRP1-B
UniProt Synonym Protein Names
Facilitates chromatin transcription complex subunit SSRP1-B; Recombination signal sequence recognition protein 1-B
UniProt Primary Accession #
Q65WY8
UniProt Secondary Accession #
Q0DK89
UniProt Related Accession #
Q65WY8
UniProt Comments
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. Binds specifically to double-stranded DNA .