Endoribonuclease Dicer homolog 3 (DCL3), Recombinant Protein
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Endoribonuclease Dicer homolog 3 (DCL3), Recombinant Protein

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Cat: RP01936
Size: 0.05 mg (E-Coli)/ 0.05 mg (Yeast)/ 0.2 mg (E-Coli)/ 0.5 mg (E-Coli)/ 0.05 mg (Baculovirus)/ 0.2 mg (Yeast)/ 0.5 mg (Yeast)/ 0.1 mg (Baculovirus)/ 0.05 mg (Mammalian-Cell)/ 1 mg (E-Coli)/ 0.5 mg (Baculovirus)/ 1 mg (Yeast)/ 0.1 mg (Mammalian-Cell)/ 1 mg (B
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:

Product Info

Full Product Name
Recombinant Arabidopsis thaliana Endoribonuclease Dicer homolog 3 (DCL3) , partial
Product Gene Name
DCL3 recombinant protein
Product Synonym Gene Name
DCL3
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Sequence
EDELIELERK IQHEFSAKFL LKEAITHSSL RESYSYERLE FLGDSVLDFL ITRHLFNTYE QTGPGEMTDL RSACVNNENF AQVAVKNNLH THLQRCATVL ETQINDYLMS FQKPDETGRS IPSIQGPKAL GDVVESIAGA LLIDTRLDL
Sequence Positions
1195-1343. Partial, including the RNase III 2 Domain
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
172,014 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
Endoribonuclease

NCBI/Uniprot Data

NCBI Accession #
NP_001154662.2
NCBI GI #
334185717
NCBI GenBank Nucleotide #
NM_001161190.2
NCBI GeneID
823508
NCBI Official Full Name
dicer-like 3
NCBI Official Symbol
DCL3
NCBI Official Synonym Symbols
ATDCL3; dicer-like 3; DICER-LIKE 3
NCBI Protein Information
dicer-like 3
NCBI Summary
Encodes a ribonuclease III family protein that is required for endogenous RDR2-dependent siRNA (but not miRNA) formation.
UniProt Gene Name
DCL3
UniProt Synonym Gene Names
AtDCL3
UniProt Protein Name
Endoribonuclease Dicer homolog 3
UniProt Synonym Protein Names
Dicer-like protein 3; AtDCL3
UniProt Primary Accession #
Q9LXW7
UniProt Related Accession #
Q9LXW7
UniProt Comments
Ribonuclease (RNase) III involved in RNA-mediated post-transcriptional gene silencing (PTGS). Involved in the processing of repeat-associated small interfering RNAs (ra-siRNAs, derived from heterochromatin and DNA repeats such as transposons) by cleaving small dsRNAs into 24 nucleotide ra-siRNAs. Plays a role in antiviral RNA silencing. Involved in the production of viral siRNAs derived from the cabbage leaf curl virus (CaLCuV) and tobacco rattle virus (TRV). Targeted by the viral silencing suppressor (VSR) protein 2b of the cucumber mosaic virus (CMV) that inactivates DCL3 function in RNA silencing. Acts redundantly with DICER-LIKE 1 (DCL1) to promote flowering via repression of FLOWERING LOCUS C (FLC). Does not seem to be involved in microRNAs (miRNAs) processing.

For research use only, not for clinical use.