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Elongator complex protein 3 (HAG3), Recombinant Protein
Cat: RP01741
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:
Product Info
Full Product Name
Recombinant Arabidopsis thaliana Elongator complex protein 3 (HAG3) , partial
Product Gene Name
HAG3 recombinant protein
Product Synonym Gene Name
HAG3
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
63,694 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
11S globulin seed storage protein
NCBI/Uniprot Data
NCBI Accession #
NP_568725.1
NCBI GI #
18423134
NCBI GenBank Nucleotide #
NM_124412.3
NCBI GeneID
835098
NCBI Official Full Name
radical SAM domain-containing protein / GCN5-related N-acetyltransferase (GNAT) family protein
NCBI Official Symbol
ELO3
NCBI Official Synonym Symbols
AtELP3; EAST1; ELONGATA 3; Elongator protein 3; ELP3; enhancer-of-asymmetric leaves-two 1; HAC8; HAG3; HISTONE ACETYLTRANSFERASE 8; HISTONE ACETYLTRANSFERASE OF THE GNAT FAMILY 3; MXI22.3; MXI22_3
NCBI Protein Information
radical SAM domain-containing protein / GCN5-related N-acetyltransferase (GNAT) family protein
NCBI Summary
A subunit of Elongator, a histone acetyl transferase complex, consisting of six subunits (ELP1#AeiELP6), that copurifies with the elongating RNAPII in yeast and humans. Three Arabidopsis thaliana genes, encoding homologs of the yeast Elongator subunits ELP1, ELP3 (histone acetyl transferase), and ELP4 are responsible for the narrow leaf phenotype in elongata mutants and for reduced root growth that results from a decreased cell division rate. Two lines with RNAi constructs directed against HAG3 grow normally and can produce root calli, but have defects in agrobacterium-mediated transformation.
UniProt Gene Name
HAG3
UniProt Synonym Gene Names
AtELP3
UniProt Protein Name
Elongator complex protein 3
UniProt Synonym Protein Names
Elongator component 3
UniProt Primary Accession #
Q93ZR1
UniProt Secondary Accession #
Q9FK40
UniProt Related Accession #
Q93ZR1
UniProt Comments
Histone acetyltransferase component of the large multiprotein complex Elongator that is involved in the regulation of transcription initiation and elongation (PubMed:20080602). May also have a methyltransferase activity (PubMed:20080602). Promotes organs development by modulating cell division rate (PubMed:20080602). Required for auxin distribution or signaling (PubMed:20080602). Required for meristem cell cycle activation at the time of germination (PubMed:23969312). Probably required for DNA replication-coupled histone acetylation (PubMed:22026817). Involved in tRNA wobble uridine modification (PubMed:20398216). Mediates the establishment of leaf polarity independently of AS2 and the ta-siRNA-related pathway (PubMed:21700721). Potential a-tubulin acetyltransferase (PubMed:22404109). Negatively regulates the expression of genes that participate in UV-B responses, such as DNA repair enzymes and enzymes that participate in sunscreen pigment biosynthesis (PubMed:25907565).
For research use only, not for clinical use.