E3 ubiquitin-protein ligase COP1 (COP1), Recombinant Protein
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E3 ubiquitin-protein ligase COP1 (COP1), Recombinant Protein

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Cat: RP01128
Size: 0.02 mg (E-Coli)/ 0.02 mg (Yeast)/ 0.1 mg (E-Coli)/ 0.1 mg (Yeast)/ 0.02 mg (Baculovirus)/ 0.02 mg (Mammalian-Cell)/ 0.1 mg (Baculovirus)/ 1 mg (E-Coli)/ 1 mg (Yeast)/ 0.1 mg (Mammalian-Cell)/ 1 mg (Baculovirus)/ 0.5 mg (Mammalian-Cell)
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:

Product Info

Full Product Name
Recombinant Arabidopsis thaliana E3 ubiquitin-protein ligase COP1 (COP1) , partial
Product Gene Name
COP1 recombinant protein
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Sequence
TFTRYSRLRV IAEIRHGDIF HSANIVSSIE FDRDDELFAT AGVSRCIKVF DFSSVVNEPA DMQCPIVEMS TRSKLSCLSW NKHEKNHIAS SDYEGIVTVW DVTTRQSLME YEEHEKRAWS VDFSRTEPSM LVSGSDDCKV KVWCTRQEAS VINIDMKANI CCVKYNPGSS NYIAVGSADH HIHYYDLRNI SQPLHVFSGH KKAVSYVKFL SNNELASAST DSTLRLWDVK DNLPVRTFRG HTNEKNFVGL TVNSEYLACG SETNEVYVYH KEITRPVTSH RFGSPDMDDA EEEAGSYFIS AVCWKSDSPT MLTANSQGTI KVLVLAA
Sequence Positions
349-675aa; Partial
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
76,188 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
E3 ubiquitin-protein ligase

NCBI/Uniprot Data

NCBI Accession #
NP_180854.1
NCBI GI #
15225760
NCBI GenBank Nucleotide #
NM_128855.4
NCBI GeneID
817857
NCBI Official Full Name
Transducin/WD40 repeat-like superfamily protein
NCBI Official Symbol
COP1
NCBI Official Synonym Symbols
ARABIDOPSIS THALIANA CONSTITUTIVE PHOTOMORPHOGENIC 1; ATCOP1; CONSTITUTIVE PHOTOMORPHOGENIC 1; DEETIOLATED MUTANT 340; DET340; EMB168; EMBRYO DEFECTIVE 168; FUS1; FUSCA 1; T21L14.11; T21L14_11
NCBI Protein Information
Transducin/WD40 repeat-like superfamily protein
NCBI Summary
Represses photomorphogenesis and induces skotomorphogenesis in the dark. Contains a ring finger zinc-binding motif, a coiled-coil domain, and several WD-40 repeats, similar to G-beta proteins. The C-terminus has homology to TAFII80, a subunit of the TFIID component of the RNA polymerase II of Drosophila. Nuclear localization in the dark and cytoplasmic in the light.
UniProt Gene Name
COP1
UniProt Protein Name
E3 ubiquitin-protein ligase COP1
UniProt Synonym Protein Names
Constitutive photomorphogenesis protein 1
UniProt Primary Accession #
P43254
UniProt Secondary Accession #
O23974; O23975; O48770; Q1JPL6
UniProt Related Accession #
P43254
UniProt Comments
E3 ubiquitin-protein ligase that acts as a repressor of photomorphogenesis and as an activator of etiolation in darkness. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Represses photomorphogenesis in darkness by mediating ubiquitination and subsequent proteasomal degradation of light-induced transcription factors such as HY5, HYH and LAF1. Down-regulates MYB21, probably via ubiquitination process. Light stimuli abrogate the repression of photomorphogenesis, possibly due to its localization to the cytoplasm. Could play a role in switching between skotomorphogenetic and photomorphogenetic pathways. Mediates the ubiquitination-dependent degradation of HY5 in the darkness during seedling development (e.g. hypocotyl growth) (PubMed:26474641). Represses CIP7 in darkness (PubMed:9668129).

For research use only, not for clinical use.