E3 ubiquitin-protein ligase BRE1-like 1 (HUB1), Recombinant Protein
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E3 ubiquitin-protein ligase BRE1-like 1 (HUB1), Recombinant Protein

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Cat: RP02107
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:

Product Info

Full Product Name
Recombinant Arabidopsis thaliana E3 ubiquitin-protein ligase BRE1-like 1 (HUB1) , partial
Product Gene Name
HUB1 recombinant protein
Product Synonym Gene Name
HUB1
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
99,719 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
E3 ubiquitin-protein ligase

NCBI/Uniprot Data

NCBI Accession #
NP_182022.2
NCBI GI #
30689877
NCBI GenBank Nucleotide #
NM_130060.4
NCBI GeneID
819104
NCBI Official Full Name
histone mono-ubiquitination 1
NCBI Official Symbol
HUB1
NCBI Official Synonym Symbols
AT2G44960; histone mono-ubiquitination 1; RDO4; REDUCED DORMANCY 4; T14P1.25; T14P1_25
NCBI Protein Information
histone mono-ubiquitination 1
NCBI Summary
The gene encodes one of two orthologous E3 ubiquitin ligases in Arabidopsis that are involved in monoubiquitination of histone H2B.
UniProt Gene Name
HUB1
UniProt Synonym Gene Names
; AtBRE1; AtHUB1
UniProt Protein Name
E3 ubiquitin-protein ligase BRE1-like 1
UniProt Synonym Protein Names
Protein HISTONE MONOUBIQUITINATION 1; AtHUB1; Protein REDUCED DORMANCY 4
UniProt Primary Accession #
Q8RXD6
UniProt Secondary Accession #
O22156; O22157
UniProt Related Accession #
Q8RXD6
UniProt Comments
E3 ubiquitin-protein ligase that monoubiquitinates H2B to form H2BK143ub1. H2BK143ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for H3K4me and maybe H3K79me. It thereby plays a central role in histone code and gene regulation. Forms a ubiquitin ligase complex in cooperation with the E2 enzyme UBC2/RAD6. Required for the regulation of flowering time and defense against necrotrophic fungal pathogens (PubMed:12535538, PubMed:17329565, PubMed:17329563, PubMed:19286969). Involved in the control of seed dormancy and germination (PubMed:21799800).

For research use only, not for clinical use.