NCBI Accession #
NP_186782.2
NCBI GenBank Nucleotide #
NM_110999.7
NCBI Official Full Name
DP-E2F-like protein 3
NCBI Official Symbol
DEL3
NCBI Official Synonym Symbols
DP-E2F-like protein 3; DP-E2F-LIKE PROTEIN 3; E2F-LIKE 2; E2FF; E2L2; T22N4.4; T22N4_4
NCBI Protein Information
DP-E2F-like protein 3
NCBI Summary
Member of the E2F transcription factors, (cell cycle genes), key components of the cyclin D/retinoblastoma/E2F pathway.
UniProt Synonym Gene Names
DEL3; E2L2; ELP1
UniProt Protein Name
E2F transcription factor-like E2FF
UniProt Synonym Protein Names
DP-E2F-like protein 3; E2F-like repressor E2L2
UniProt Primary Accession #
Q8RWL0
UniProt Secondary Accession #
Q9SRI0
UniProt Related Accession #
Q8RWL0
UniProt Comments
Inhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Does not bind retinoblastoma-related proteins. Acts as a growth regulator but is not associated with changes in the expression of cell cycle marker genes or in nuclear ploidy levels. Has no effect on cell proliferation, but may repress cell wall biosynthesis genes during cell elongation in differentiated cells.