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DNA repair helicase UVH6 (UVH6), Recombinant Protein
Cat: RP01482
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:
Product Info
Full Product Name
Recombinant Arabidopsis thaliana DNA repair helicase UVH6 (UVH6) , partial
Product Gene Name
UVH6 recombinant protein
Product Synonym Gene Name
UVH6
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
86,236 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
NCBI/Uniprot Data
NCBI Accession #
NP_171818.1
NCBI GI #
15218736
NCBI GenBank Nucleotide #
NM_100201.3
NCBI GeneID
839557
NCBI Official Full Name
RAD3-like DNA-binding helicase protein
NCBI Official Symbol
UVH6
NCBI Official Synonym Symbols
ARABIDOPSIS THALIANA XERODERMA PIGMENTOSUM GROUP D; ATXPD; ULTRAVIOLET HYPERSENSITIVE 6
NCBI Protein Information
RAD3-like DNA-binding helicase protein
NCBI Summary
UV damage and heat induce a common stress response in plants that leads to tissue death and reduced chloroplast function. The UVH6 product is suggested to be a negative regulator of this response.
UniProt Gene Name
XPD
UniProt Synonym Gene Names
TFIIH subunit XPD; AtUVH6; AtXPD
UniProt Protein Name
General transcription and DNA repair factor IIH helicase subunit XPD
UniProt Synonym Protein Names
ERCC2 homolog; RAD3 homolog; UV hypersensitive protein 6; AtUVH6; XPD homolog; AtXPD
UniProt Primary Accession #
Q8W4M7
UniProt Secondary Accession #
Q9SE44; Q9ZVS1
UniProt Related Accession #
Q8W4M7
UniProt Comments
ATP-dependent 5'-3' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATP-dependent helicase activity of XPD is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. XPD acts by forming a bridge between CAK and the core-TFIIH complex . Essential during plant growth (PubMed:12857822). May negatively regulate a common response program mediated by UV damage and heat stress, that leads to tissue death and reduced chloroplast function (PubMed:9414549).
For research use only, not for clinical use.