DNA mismatch repair protein Msh2 (MSH2), Recombinant Protein
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DNA mismatch repair protein Msh2 (MSH2), Recombinant Protein

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Cat: RP01330
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:

Product Info

Full Product Name
Recombinant Arabidopsis thaliana DNA mismatch repair protein Msh2 (MSH2) , partial
Product Gene Name
MSH2 recombinant protein
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
105,503 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
DNA mismatch repair protein

NCBI/Uniprot Data

NCBI Accession #
NP_566804.3
NCBI GI #
42565226
NCBI GenBank Nucleotide #
NM_113607.4
NCBI GeneID
821383
NCBI Official Full Name
MUTS homolog 2
NCBI Official Symbol
MSH2
NCBI Official Synonym Symbols
ATMSH2; MUTS homolog 2
NCBI Protein Information
MUTS homolog 2
NCBI Summary
Encodes a DNA mismatch repair homolog of human MutS gene, MSH6. MSH2 is involved in maintaining genome stability and repressing recombination of mismatched heteroduplexes.There are four MutS genes in Arabidopsis, MSH2, MSH3, MSH6, and MSH7, which all act as heterodimers and bind to 51-mer duplexes. MSH2 has different binding specificity to different mismatches in combination with MSH3, MSH6, or MSH7.
UniProt Gene Name
MSH2
UniProt Synonym Gene Names
AtMSH2
UniProt Protein Name
DNA mismatch repair protein MSH2
UniProt Synonym Protein Names
MutS protein homolog 2
UniProt Primary Accession #
O24617
UniProt Secondary Accession #
Q9SQ60; Q9ZR93
UniProt Related Accession #
O24617
UniProt Comments
Component of the post-replicative DNA mismatch repair system (MMR). Forms three different heterodimers: MutS alpha (MSH2-MSH6 heterodimer), MutS beta (MSH2-MSH3 heterodimer) and MutS gamma (MSH2-MSH7 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. MutS alpha and MutS beta recognize single base mismatches and trinucleotide insertion-deletion loops (IDL) in the DNA. MutS gamma recognizes specifically the T/G single base mismatch. Plays a role in DNA homologous recombination repair and has a broad range of anti-recombination effects. Can suppress recombination between divergent direct repeats in somatic cells and possesses an anti-recombination meiotic effect. Is involved in a UV-B-induced DNA damage response pathway.

For research use only, not for clinical use.