NCBI Accession #
NP_001233889.1
NCBI GenBank Nucleotide #
NM_001246960.2
NCBI Official Full Name
DNA-directed RNA polymerase II subunit RPB2
NCBI Official Symbol
rpb2
NCBI Protein Information
DNA-directed RNA polymerase II subunit RPB2
UniProt Synonym Gene Names
RNA polymerase II subunit 2; RNA polymerase II subunit B2
UniProt Protein Name
DNA-directed RNA polymerase II subunit RPB2
UniProt Synonym Protein Names
DNA-directed RNA polymerase II 135 kDa polypeptide
UniProt Primary Accession #
Q42877
UniProt Related Accession #
Q42877
UniProt Comments
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template .