DNA (cytosine-5)-methyltransferase DRM2 (DRM2), Recombinant Protein
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DNA (cytosine-5)-methyltransferase DRM2 (DRM2), Recombinant Protein

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Cat: RP02099
Size: 0.05 mg (E-Coli)/ 0.05 mg (Yeast)/ 0.2 mg (E-Coli)/ 0.05 mg (Baculovirus)/ 0.5 mg (E-Coli)/ 0.2 mg (Yeast)/ 0.05 mg (Mammalian-Cell)/ 0.1 mg (Baculovirus)/ 0.5 mg (Yeast)/ 1 mg (E-Coli)/ 0.5 mg (Baculovirus)/ 0.1 mg (Mammalian-Cell)/ 1 mg (Yeast)/ 1 mg (B
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:

Product Info

Full Product Name
Recombinant Arabidopsis thaliana DNA (cytosine-5)-methyltransferase DRM2 (DRM2) , partial
Product Gene Name
DRM2 recombinant protein
Product Synonym Gene Name
DRM2
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Sequence
PGLITHRSLP ELARGPPFFY YENVALTPKG VWETISRHLF EIPPEFVDSK YFCVAARKRG YIHNLPINNR FQIQPPPKYT IHDAFPLSKR WWPEWDKRTK LNCILTCTGS AQLTNRIRVA LEPYNEEPEP PKHVQRYVID QCKKWNLVWV GKNKAAPLEP DEMESILGFP KNHTRGGGMS RTERFKSLGN SFQVDTVAYH LSVLKPIFPH GINVLSLFTG IGGGEVALHR LQIKMKLVVS VEISKVNRNI LKDFWEQTNQ TGELIEFSDI QHLTNDTIEG LMEKYGGFDL VIGGSPCNNL AGGNRVSRVG LEGDQSSLFF EYCRILEVVR ARMRGS
Sequence Positions
291-626. Partial, inclduing the SAM-dependent MTase DRM-type Domain
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
70,431 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
DNA

NCBI/Uniprot Data

NCBI Accession #
NP_196966.2
NCBI GI #
30684984
NCBI GenBank Nucleotide #
NM_121466.3
NCBI GeneID
831315
NCBI Official Full Name
domains rearranged methyltransferase 2
NCBI Official Symbol
DRM2
NCBI Official Synonym Symbols
AT5G14630; DMT7; domains rearranged methyltransferase 2; NA METHYLTRANSFERASE; T15N1.110; T15N1_110
NCBI Protein Information
domains rearranged methyltransferase 2
NCBI Summary
A putative DNA methyltransferase with rearranged catalytic domains; similar to mammalian DNMT3 methyltransferases; contains UBA domains. The 3'-end proximal part of the gene coding region is highly methylated at both adenine and cytosine residues.
UniProt Gene Name
DRM2
UniProt Protein Name
DNA (cytosine-5)-methyltransferase DRM2
UniProt Synonym Protein Names
Protein DOMAINS REARRANGED METHYLASE 2
UniProt Primary Accession #
Q9M548
UniProt Secondary Accession #
Q9LYJ7; Q9LYJ8
UniProt Related Accession #
Q9M548
UniProt Comments
Involved in de novo DNA methylation. Controls asymmetric and CpNpG methylation. Required for FWA gene silencing but not for the maintenance of SUP gene silencing. Functionally redundant to CMT3 to maintain non-CpG methylation. Involved in RNA-directed DNA methylation (RdDM) (PubMed:12121623, PubMed:12151602, PubMed:14680640). Acts as major DNA methyltransferase in the RdDM pathway, and is essential for RNA-directed de novo DNA methylation of cytosines in all sequence contexts (PubMed:21060858, PubMed:21212233). Associates with long non-coding RNA (lncRNA) produced by RNA polymerase V (Pol V). This association is dependent on AGO4 and IDN2, and results in DNA methylation of RdDM target loci (PubMed:24862207).

For research use only, not for clinical use.