NCBI Accession #
XP_015623486.1
NCBI GenBank Nucleotide #
XM_015768000.1
NCBI Official Full Name
cytoplasmic tRNA 2-thiolation protein 1
NCBI Official Symbol
LOC4330815
NCBI Official Synonym Symbols
CTU1; NCS6
NCBI Protein Information
cytoplasmic tRNA 2-thiolation protein 1
UniProt Protein Name
Cytoplasmic tRNA 2-thiolation protein 1
UniProt Synonym Protein Names
Cytoplasmic tRNA adenylyltransferase 1
UniProt Primary Accession #
Q6Z6G6
UniProt Secondary Accession #
A0A0P0VPQ0
UniProt Related Accession #
Q6Z6G6
UniProt Comments
Plays a central role in 2-thiolation of mcm5S2U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.