Cystathionine gamma-synthase, chloroplastic (CGS1), Recombinant Protein
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Cystathionine gamma-synthase, chloroplastic (CGS1), Recombinant Protein

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Cat: RP01090
Size: 0.02 mg (E-Coli)/ 0.02 mg (Yeast)/ 0.1 mg (E-Coli)/ 0.1 mg (Yeast)/ 0.02 mg (Baculovirus)/ 0.02 mg (Mammalian-Cell)/ 0.1 mg (Baculovirus)/ 1 mg (E-Coli)/ 1 mg (Yeast)/ 0.1 mg (Mammalian-Cell)/ 1 mg (Baculovirus)/ 0.5 mg (Mammalian-Cell)
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:

Product Info

Full Product Name
Recombinant Arabidopsis thaliana Cystathionine gamma-synthase, chloroplastic (CGS1)
Product Gene Name
CGS1 recombinant protein
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Sequence
GERLGRGIVT DAITTPVVNT SAYFFKKTAE LIDFKEKRSV SFEYGRYGNP TTVVLEDKIS ALEGAESTLV MASGMCASTV MLLALVPAGG HIVTTTDCYR KTRIFMENFL PKLGITVTVI DPADIAGLEA AVNEFKVSLF FTESPTNPFL RCVDIELVSK ICHKRGTLVC IDGTFATPLN QKALALGADL VVHSATKYIG GHNDVLAGCI CGSLKLVSEI RNLHHVLGGT LNPNAAYLII RGMKTLHLRV QQQNSTAFRM AEILEAHPKV SHVYYPGLPS HPEHELAKRQ MTGFGGVVSF EIDGDIETTI KFVDSLKIPY IAPSFGGCES IVDQPAIMSY WDLPQEERLK YGIKDNLVRF SFGVEDFEDV KADILQALEA I
Sequence Positions
183-563, Full length protein
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
59,919 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
Cystathionine gamma-synthase

NCBI/Uniprot Data

NCBI Accession #
NP_186761.1
NCBI GI #
15232042
NCBI GenBank Nucleotide #
NM_110977.3
NCBI GeneID
821292
NCBI Official Full Name
Pyridoxal phosphate (PLP)-dependent transferases superfamily protein
NCBI Official Symbol
MTO1
NCBI Official Synonym Symbols
A. THALIANA CYSTATHIONINE GAMMA-SYNTHASE 1; A. thaliana cystathionine gamma-synthetase 1; AtCGS1; AtCYS1; ATCYS1; CGS; CGS1; CYSTATHIONINE GAMMA-SYNTHASE; CYSTATHIONINE GAMMA-SYNTHASE 1; CYSTATHIONINE-GAMMA-SYNTHASE; METHIONINE OVERACCUMULATION 1; T4P13.1
NCBI Protein Information
Pyridoxal phosphate (PLP)-dependent transferases superfamily protein
NCBI Summary
encodes a cystathionine gamma-synthase, which performs the first committed step in methionine biosynthesis. A conserved motif of 13 amino acids in the first exon is required for posttranscriptional autoregulation. This enzyme shares the same substrate as threonine synthase (TS) and its absence transcriptionally affects 8 genes in the genome.
UniProt Gene Name
CGS1
UniProt Synonym Gene Names
; AtCGS1Curated
UniProt Protein Name
Cystathionine gamma-synthase 1, chloroplastic
UniProt Synonym Protein Names
METHIONINE OVERACCUMULATION 1
UniProt Primary Accession #
P55217
UniProt Secondary Accession #
P92944; P93038; Q42550
UniProt Related Accession #
P55217
UniProt Comments
Catalyzes the first committed step of methionine (Met) biosynthesis. Catalyzes the formation of L-cystathionine from homoserine esters and L-cysteine, via a gamma-replacement reaction. Substrate preference for cystathionine synthesis is O-phospho-L-homoserine (OPH) > O4-succinyl-L-homoserine (OSH) >> O-acetyl-L-homoserine (OAH). Is able, at extremely low rate, to catalyze a gamma-elimination of OPH in the absence of cysteine to produce inorganic phosphate (Pi), 2-oxobutanoate and ammonia.

For research use only, not for clinical use.