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Cyclic nucleotide-gated ion channel 1 (CNGC1), Recombinant Protein
Cat: RP00010
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:
Product Info
Full Product Name
Recombinant Arabidopsis thaliana Cyclic nucleotide-gated ion channel 1 (CNGC1)
Product Synonym Names
Recombinant Cyclic nucleotide-gated ion channel 1 (CNGC1); Cyclic nucleotide-gated ion channel 1; AtCNGC1; Cyclic nucleotide- and calmodulin-regulated ion channel 1
Product Gene Name
CNGC1 recombinant protein
Product Synonym Gene Name
CNGC1
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Sequence
MNFRQEKFVR FQDWKSDKTS SDVEYSGKNE IQTGIFQRTI SSISDKFYRS FESSSARIKL FKRSYKSYSF KEAVSKGIGS THKILDPQGP FLQRWNKIFV LACIIAVSLD PLFFYVPIID DAKKCLGIDK KMEITASVLR SFTDVFYVLH IIFQFRTGFI APSSRVFGRG VLVEDKREIA KRYLSSHFII DILAVLPLPQ MVILIIIPHM RGSSSLNTKN MLKFIVFFQY IPRFIRIYPL YKEVTRTSGI LTETAWAGAA FNLFLYMLAS HVFGAFWYLF SIERETVCWK QACERNNPPC ISKLLYCDPE TAGGNAFLNE SCPIQTPNTT LFDFGIFLDA LQSGVVESQD FPQKFFYCFW WGLQNLSSLG QNLKTSTYIW EICFAVFISI AGLVLFSFLI GNMQTYLQST TTRLEEMRVK RRDAEQWMSH RLLPENLRKR IRRYEQYKWQ ETRGVDEENL LSNLPKDLRR DIKRHLCLAL LMRVPMFEKM DEQLLDALCD RLQPVLYTEE SYIVREGDPV DEMLFIMRGK LLTITTNGGR TGFLNSEYLG AGDFCGEELL TWALDPHSSS NLPISTRTVR ALMEVEAFAL KADDLKFVAS QFRRLHSKQL RHTFRYYSQQ WKTWAACFIQ AAWRRYIKKK LEESLKEEEN RLQDALAKEA CGSSPSLGAT IYASRFAANI LRTIRRSGSV RKPRMPERMP PMLLQKPAEP DFNSDD
Sequence Positions
1-716
Chromosome Location
Chromosome: 5; NC_003076.8 (21537721..21541029, complement). Location: chromosome: 5
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
83,097 Da
Storage
Store at -20℃. For extended storage, store at -20 or -80℃.
Protein Family
Cyclic nucleotide-gated ion channel
NCBI/Uniprot Data
NCBI Accession #
NP_200125.1
NCBI GI #
15238657
NCBI GenBank Nucleotide #
NM_124692.3
NCBI GeneID
835393
NCBI Official Full Name
cyclic nucleotide-gated ion channel 1
NCBI Official Symbol
CNGC1
NCBI Official Synonym Symbols
ATCNGC1; CNGC1; cyclic nucleotide gated channel 1; CYCLIC NUCLEOTIDE-GATED CHANNEL 1; MFH8.6; MFH8_6
NCBI Protein Information
cyclic nucleotide-gated ion channel 1
UniProt Gene Name
CNGC1
UniProt Synonym Gene Names
AtCNGC1
UniProt Protein Name
Cyclic nucleotide-gated ion channel 1
UniProt Synonym Protein Names
Cyclic nucleotide- and calmodulin-regulated ion channel 1
UniProt Entry Name
CNGC1_ARATH
UniProt Primary Accession #
O65717
UniProt Related Accession #
T51354
UniProt Comments
Function: Acts as cyclic nucleotide-gated ion channel. Can be activated by cyclic AMP which leads to an opening of the cation channel. May be responsible for cAMP-induced calcium entry in cells and thus should be involved in the calcium signal transduction. Could transport K+, Na+ and Pb2+.Subunit structure: Homotetramer or heterotetramer Potential. Binds calmodulin-2/3/5 with a higher affinity than calmodulin-1/4.Subcellular location: Cell membrane; Multi-pass membrane protein Potential. Tissue specificity: Expressed in the whole plant but only weakly in roots.Domain: The binding of calmodulin to the C-terminus might interfere with cyclic nucleotide binding and thus channel activation By similarity.Disruption phenotype: Plants exhibit an improved tolerance to Pb2+.Sequence similarities: Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. Contains 1 cyclic nucleotide-binding domain.Contains 1 IQ domain.
For research use only, not for clinical use.