Cullin-4 (CUL4), Recombinant Protein
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Cullin-4 (CUL4), Recombinant Protein

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Cat: RP01528
Size: 0.05 mg (E-Coli)/ 0.05 mg (Yeast)/ 0.2 mg (E-Coli)/ 0.5 mg (E-Coli)/ 0.05 mg (Baculovirus)/ 0.2 mg (Yeast)/ 0.5 mg (Yeast)/ 0.1 mg (Baculovirus)/ 0.05 mg (Mammalian-Cell)/ 1 mg (E-Coli)/ 0.5 mg (Baculovirus)/ 1 mg (Yeast)/ 0.1 mg (Mammalian-Cell)/ 1 mg (B
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:

Product Info

Full Product Name
Recombinant Arabidopsis thaliana Cullin-4 (CUL4) , partial
Product Gene Name
CUL4 recombinant protein
Product Synonym Gene Name
CUL4
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Sequence
MSLPTKRSTF SAASASDDSS YSSPPMKKAK NDLHHSPQHP NTADKVVGFH MEEDPTPAAA NLSRKKATLP QPTKKFVIKL NKAKPTLPTN FEENTWEKLQ SAIRAIFLKK KISFDLESLY QAVDNLCLHK LDGKLYDQIE KECEEHISAA
Sequence Positions
1-150. Partial
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
91,471 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
Cullin

NCBI/Uniprot Data

NCBI Accession #
NP_568658.1
NCBI GI #
18422645
NCBI GenBank Nucleotide #
NM_123990.3
NCBI GeneID
834663
NCBI Official Full Name
cullin4
NCBI Official Symbol
CUL4
NCBI Official Synonym Symbols
ATCUL4; cullin4; MDE13.3; MDE13_3
NCBI Protein Information
cullin4
NCBI Summary
Arabidopsis CULLIN4 (CUL4) forms an E3 ubiquitin ligase with the CDD complex and a common catalytic subunit RBX1 in mediating light control of development. This CUL4-based E3 ligase is essential for the repression of photomorphogenesis. The partial loss of CUL4 function resulted in a constitutive photomorphogenic phenotype with respect to morphogenesis and light-regulated gene expression. CUL4 exhibits a synergistic genetic interaction with COP10 and DET1.
UniProt Gene Name
CUL4
UniProt Synonym Gene Names
AtCUL4
UniProt Protein Name
Cullin-4
UniProt Primary Accession #
Q8LGH4
UniProt Secondary Accession #
Q84LL5; Q8RWT9; Q9FGP0
UniProt Related Accession #
Q8LGH4
UniProt Comments
Component of the CUL4-RBX1-CDD (COP10-DDB1a-DET1) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Participates in the CDD complex to light-mediated control of development. May repress photomorphogenesis through enhancing COP1 E3 ubiquitin-protein ligase activity. Acts together with the CUL4-DDB1-COP1-SPA E3 ubiquitin-protein ligase complexes in the repression of photomorphogenesis and flowering time. Component ot the CUL4-RBX1-DDB1-PRL1 E3 ubiquitin-protein ligase complex which mediates ubiquitination and subsequent degradation of AKIN10. Component of the CUL4-RBX1-DDB1-DWA1/DWA2 E3 ubiquitin-protein ligase complex that acts as negative regulator in abscisic acid (ABA) signaling and may target ABI5 for degradation.

For research use only, not for clinical use.