NCBI Accession #
NP_190569.2
NCBI GenBank Nucleotide #
NM_114860.4
NCBI Official Full Name
casein kinase II, alpha chain 2
NCBI Official Symbol
CKA2
NCBI Official Synonym Symbols
''casein kinase II; alpha chain 2; ALPHA CHAIN 2; alpha chain 2''; ATCKA2; ATPK15D; casein kinase II; CASEIN KINASE II
NCBI Protein Information
casein kinase II, alpha chain 2
NCBI Summary
Encodes the casein kinase II (CK2) catalytic subunit (alpha).
UniProt Synonym Gene Names
CK II; AtCKA2
UniProt Protein Name
Casein kinase II subunit alpha-2
UniProt Synonym Protein Names
Casein kinase alpha 2
UniProt Primary Accession #
Q08466
UniProt Secondary Accession #
Q8H120; Q8H765; Q9SN18
UniProt Related Accession #
Q08466
UniProt Comments
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates . The alpha chain contains the catalytic site. The tetrameric holoenzyme CK2, composed of two alpha and two beta subunits, phosphorylates the transcription factor PIF1 after an exposure to light, resulting in a proteasome-dependent degradation of PIF1 and promotion of photomorphogenesis (PubMed:21330376). CK2 phosphorylates translation initiation factors. May participate in the regulation of the initiation of translation (PubMed:19509278). Acts as circadian clock component that maintains the correct period length through phosphorylation of CCA1 (PubMed:21900482). May act as an ectokinase that phosphorylates several extracellular proteins.