NCBI Accession #
NP_001330897.1
NCBI GenBank Nucleotide #
NM_001345276.1
NCBI Official Full Name
D-aminoacid aminotransferase-like PLP-dependent enzymes superfamily protein
NCBI Official Symbol
ADCL
NCBI Official Synonym Symbols
4-amino-4-deoxychorismate lyase; MTI20.10; MTI20_10
NCBI Protein Information
D-aminoacid aminotransferase-like PLP-dependent enzymes superfamily protein
NCBI Summary
ADCL encodes a protein that acts as a 4-amino-4-deoxychorismate lyase. It catalyzes the production 4-aminobenzoate (pABA) production which is required for folate biosynthesis. The enzyme localizes to chloroplasts based on an import assay and GFP localization experiments.
UniProt Synonym Gene Names
AtADCL
UniProt Protein Name
D-amino-acid transaminase, chloroplastic
UniProt Synonym Protein Names
Aminodeoxychorismate lyase
UniProt Primary Accession #
Q8L493
UniProt Secondary Accession #
Q9FJM9
UniProt Related Accession #
Q8L493
UniProt Comments
Amino acid aminotransferase showing activity for D-Asp and D-Ala as amino donors with 2-oxoglutarate as an amino acceptor. Can also use D-Met, D-Tyr, D-Phe, D-Gln, D-Trp and D-Asn as substrates, but no activity with L-Asp, L-Ala, L-Leu, L-Ile or L-Val. Catalyzes also the reverse reaction where an amino group is transferred from D-Glu to pyruvate or oxaloacetate to produce D-Ala or D-Asp, respectively. Also involved in folate biosynthesis, acting as an aminodeoxychorismate lyase converting 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate (PABA)(PubMed:15500462).