NCBI Accession #
NP_171920.1
NCBI GenBank Nucleotide #
NM_100305.4
NCBI Official Full Name
AUX/IAA transcriptional regulator family protein
NCBI Official Symbol
SHY2
NCBI Official Synonym Symbols
F19P19.32; F19P19_32; IAA3; indole-3-acetic acid inducible 3; SHORT HYPOCOTYL 2
NCBI Protein Information
AUX/IAA transcriptional regulator family protein
NCBI Summary
SHY2/IAA3 regulates multiple auxin responses in roots. It is induced rapidly by IAA, and has been shown to be phosphorylated by oat phytochrome A in vitro.
UniProt Synonym Gene Names
SHY2
UniProt Protein Name
Auxin-responsive protein IAA3
UniProt Synonym Protein Names
Indoleacetic acid-induced protein 3; Short hypocotyl; Suppressor of HY2
UniProt Primary Accession #
Q38822
UniProt Secondary Accession #
O04741
UniProt Related Accession #
Q38822
UniProt Comments
Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations. Repression is thought to result from the interaction with auxin response factors (ARFs), proteins that bind to the auxin-responsive promoter element (AuxRE). Plays a central role in auxin regulation of root growth, in gravitropism, and in lateral root formation (PubMed:9895319). Regulated by an auxin-induced protein turnover (PubMed:14617065). Formation of heterodimers with ARF proteins may alter their ability to modulate early auxin response genes expression. When activated by cytokinin, restricts the expression of the PIN genes to the vascular transition zone (PubMed:19039136). Induction of SHY2 in the vascular transition zone restricts BRX expression to down-regulate PIN3 and thus limit meristem growth, but proper SHY2 expression requires BRX (PubMed:21149702). Involved in meristem growth and in determining its size (PubMed:20605455). May participate in strigolactone signaling to regulate meristem size and lateral root formation (PubMed:23425316).