NCBI Accession #
NP_197231.1
NCBI GenBank Nucleotide #
NM_121735.5
NCBI Official Full Name
autophagy protein Apg5 family
NCBI Official Symbol
APG5
NCBI Official Synonym Symbols
ATATG5; ATG5; AUTOPHAGY 5; MKP11.20; MKP11_20
NCBI Protein Information
autophagy protein Apg5 family
NCBI Summary
Autophagy protein ATG5. Forms a conjugate with ATG12 with an essential role in plant nutrient recycling. Mutants missing ATG5 display early senescence and are hypersensitive to nitrogen or carbon starvation, accompanied by a more rapid loss of organellar and cytoplasmic proteins.
UniProt Synonym Gene Names
AtAPG5
UniProt Protein Name
Autophagy protein 5
UniProt Synonym Protein Names
Protein autophagy 5
UniProt Primary Accession #
Q9FFI2
UniProt Related Accession #
Q9FFI2
UniProt Comments
Required for autophagy. Conjugation to ATG12 is essential for plant nutrient recycling (PubMed:16040659). Involved in a negative feedback loop that modulates NPR1-dependent salicylic acid (SA) signaling and limits senescence and immunity-related programmed cell death (PCD) in plants (PubMed:19773385). Involved in complete proteolysis of chloroplast stroma proteins in senescent leaves (PubMed:23327451). Involved in the degradation of damaged peroxisomes (PubMed:24463818).