ATP-dependent DNA helicase 2 subunit KU80 (KU80), Recombinant Protein
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ATP-dependent DNA helicase 2 subunit KU80 (KU80), Recombinant Protein

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Cat: RP01049
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:

Product Info

Full Product Name
Recombinant Arabidopsis thaliana ATP-dependent DNA helicase 2 subunit KU80 (KU80) , partial
Product Gene Name
KU80 recombinant protein
Product Synonym Gene Name
KU80
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
76,688 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
ATP-dependent DNA helicase

NCBI/Uniprot Data

NCBI Accession #
NP_564520.1
NCBI GI #
18402015
NCBI GenBank Nucleotide #
NM_103701.2
NCBI GeneID
841223
NCBI Official Full Name
Ku80 family protein
NCBI Official Symbol
KU80
NCBI Official Synonym Symbols
ARABIDOPSIS THALIANA KU80 HOMOLOG; ATKU80; KU80-LIKE PROTEIN; T2J15.4
NCBI Protein Information
Ku80 family protein
NCBI Summary
Ku80 and ku70 form the heterodimer complex Ku, required for proper maintenance of the telomeric C strand. Ku regulates the extension of the telomeric G strand. Interacts with WEX, and this interaction stimulates the WEX exonuclease activity. Binds double stranded DNA breaks as a heterodimer with Ku70, involved in non-homologous end joining repair. Mutants are defective in T-DNA integration. Over expression confers increased resistance to DNA damage agents and increased susceptibility to T-DNA transformation.
UniProt Gene Name
KU80
UniProt Protein Name
ATP-dependent DNA helicase 2 subunit KU80
UniProt Synonym Protein Names
ATP-dependent DNA helicase 2 subunit 2; ATP-dependent DNA helicase II 80 kDa subunit
UniProt Primary Accession #
Q9FQ09
UniProt Secondary Accession #
Q9C7Z3; Q9LNF5
UniProt Related Accession #
Q9FQ09
UniProt Comments
Single-stranded DNA-dependent ATP-dependent helicase. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair. When associated with KU70, binds to double-stranded telomeric and non-telomeric DNA sequences, but not to single-stranded DNA. Plays a role in maintaining telomere length. Acts as a negative regulator of telomerase. Binds to and recombines double-stranded T-DNA molecules.

For research use only, not for clinical use.