ATP-dependent DNA helicase 2 subunit KU70 (KU70), Recombinant Protein
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ATP-dependent DNA helicase 2 subunit KU70 (KU70), Recombinant Protein

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Cat: RP01618
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:

Product Info

Full Product Name
Recombinant Arabidopsis thaliana ATP-dependent DNA helicase 2 subunit KU70 (KU70) , partial
Product Gene Name
KU70 recombinant protein
Product Synonym Gene Name
KU70
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
70,291 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
ATP-dependent DNA helicase

NCBI/Uniprot Data

NCBI Accession #
NP_564012.1
NCBI GI #
18394425
NCBI GenBank Nucleotide #
NM_101558.4
NCBI GeneID
838268
NCBI Official Full Name
ATP-dependent DNA helicase 2 subunit Ku70-like protein
NCBI Official Symbol
KU70
NCBI Official Synonym Symbols
ARABIDOPSIS THALIANA KU70 HOMOLOG; ATKU70; F6I1.2; F6I1_2; KU70 homolog; KU70-LIKE PROTEIN
NCBI Protein Information
ATP-dependent DNA helicase 2 subunit Ku70-like protein
NCBI Summary
Ku80 and ku70 form the heterodimer complex Ku, required for proper maintenance of the telomeric C strand. Ku regulates the extension of the telomeric G strand. Interacts with WEX, and this interaction stimulates the WEX exonuclease activity.
UniProt Gene Name
KU70
UniProt Protein Name
ATP-dependent DNA helicase 2 subunit KU70
UniProt Synonym Protein Names
ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit
UniProt Primary Accession #
Q9FQ08
UniProt Secondary Accession #
Q9FZ56
UniProt Related Accession #
Q9FQ08
UniProt Comments
Single-stranded DNA-dependent ATP-dependent helicase. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair. When associated with KU80, binds to double-stranded telomeric and non-telomeric DNA sequences, but not to single-stranded DNA. Plays a role in maintaining telomere length. Acts as a negative regulator of telomerase. Required for maintenance of the telomeric C-rich strand.

For research use only, not for clinical use.