Artocarpus integrifolia Lectin (AIA) - Colloidal Gold
Description
A tetramer double chain structure composed of 4 identical propolymers is obtained by affinity chromatography with an isoelectric pH of 7.8. The lectin is specific to blood type O (+SA) and t. Jacalin is considered a galactose-specific lectin that can be eluted with galactose or glycodisaccharide. Jacalin's post-translational proteolytic modification gives lectin a new carbohydrate binding site involving the N end of the α-chain. The structure of this protein explains its carbohydrate-binding specificity to the t antigen disaccharide Galβ1,3 galnac. Effective inhibitors of jacalin include D-galactose, β-Met-Gal, and 2-deoxy-α-D-galactose. Colloidal gold can be used to visualize the location of specific sugar parts and examine the distribution of plasma membrane glycoproteins based on the binding pattern of tree fruit lectins. Colloidal gold labeled lectins can be observed by electron microscopy.
Product Info
For research use only, not for clinical use.