Arachis hypogaea Lectin (PNA) - Pure
Description
Peanut lectin (PNA) is purified by affinity chromatography and consists of four subunits, each of about 27,000 subunits. This lectin has an isoelectric point between pH 5.5 and pH 6.5. It is carbohydrate-specific for Galβ3GalNAc with galactose-eluting sugar. Galactose and lactose are poor inhibitors, while disaccharide galactose beta (1->3)GalNAc and defatalized human red blood cell substance N (t antigen, present in many M and N blood groups) are potent inhibitors of PNA. Although peanut extract does not agglutinate untreated or trypsin-treated human red blood cells, PNA is known to agglutinate neuraminidase-treated human red blood cells. PNA can be used in clinical detection of red blood cell T-polyagglutination and detection of normal and malignant cell membranes. This lectin can be used to characterize tumor-specific antigens on the surface of malignant cells. It can be used in the isolation of mouse stem cells for bone marrow transplantation across histocompatibility barriers.
Product Info
For research use only, not for clinical use.