NCBI Accession #
NP_181254.1
NCBI GenBank Nucleotide #
NM_129273.4
NCBI Official Full Name
aquaporin PIP2-2
NCBI Official Symbol
PIP2B
NCBI Official Synonym Symbols
PIP2;2; PIP2B; plasma membrane intrinsic protein 2; PLASMA MEMBRANE INTRINSIC PROTEIN 2;2; T2N18.7; T2N18_7
NCBI Protein Information
aquaporin PIP2-2
NCBI Summary
a member of the plasma membrane intrinsic protein subfamily PIP2. localizes to the plasma membrane and exhibits water transport activity in Xenopus oocyte. expressed specifically in the vascular bundles and protein level increases slightly during leaf dev
UniProt Synonym Gene Names
PIP2B; AtPIP2;2; PIP2b
UniProt Protein Name
Aquaporin PIP2-2
UniProt Synonym Protein Names
Plasma membrane intrinsic protein 2-2; AtPIP2;2; Plasma membrane intrinsic protein 2b; PIP2b; TMP2b
UniProt Entry Name
PIP22_ARATH
UniProt Primary Accession #
P43287
UniProt Secondary Accession #
Q8L5U5; Q9SKR8
UniProt Related Accession #
D84789
UniProt Comments
Function: Water channel required to facilitate the transport of water across cell membrane. Plays an predominant role in root water uptake process in conditions of reduced transpiration, and in osmotic fluid transport. Its function is impaired by Hg2+. Inhibited by cytosolic acidosis which occurs during anoxia in roots.Subcellular location: Cell membrane; Multi-pass membrane protein. Tissue specificity: Predominantly expressed in the root, with a strong expression in the cortex, endodermis, and stele.Domain: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).Sequence similarities: Belongs to the MIP/aquaporin (TC 1.A.8) family. PIP (TC 1.A.8.11) subfamily.