NCBI Accession #
NP_174810.1
NCBI GenBank Nucleotide #
NM_103274.4
NCBI Official Full Name
annexin 1
NCBI Official Symbol
ANNAT1
NCBI Official Synonym Symbols
ANN1; ANNEXIN; annexin 1; ANNEXIN A1; AtANN1; ATOXY5; F14D7.2; F14D7_2; OXY5
NCBI Protein Information
annexin 1
NCBI Summary
Encodes a member of the annexin gene family, a diverse, multigene family of calcium-dependent, membrane-binding proteins. The protein was determined to have peroxidase activity. This activity is thought to be dependent on the presence of post-translational modifications (most likely phosphorylation). The protein was shown to be present as a mixture of monomer and homodimer. The homodimerization seems to be dependent on the presence of Ca2+ or H2O2. The dimerization was prevented by the addition of DTT, beta-mercaptoethanol and TCEP. Annat1 mRNA is expressed in flowers, roots,leaves and stems and is most abundant in stems. mRNA levels are increased in response to oxidative stress. Developmental expression patterns suggest a role in Golgi-mediated polysaccharide secretion. It is a Ca 2+-permeable transporter providing a molecular link between reactive oxygen species and cytosolic Ca 2+ in plants.
UniProt Synonym Gene Names
ANNAT1; ANX23-ATH; ATOXY5; OXY5
UniProt Protein Name
Annexin D1
UniProt Synonym Protein Names
AnnAt1; Annexin A1
UniProt Primary Accession #
Q9SYT0
UniProt Secondary Accession #
Q39001; Q42023; Q56Y94; Q96527
UniProt Related Accession #
Q9SYT0
UniProt Comments
Has a peroxidase activity. May act in counteracting oxidative stress. May also mediate regulated, targeted secretion of Golgi-derived vesicles during seedling development.