NCBI Accession #
NP_193531.1
NCBI GenBank Nucleotide #
NM_117907.3
NCBI Official Full Name
aluminum-activated, malate transporter 12
NCBI Official Symbol
ALMT12
NCBI Official Synonym Symbols
aluminum-activated; ATALMT12; malate transporter 12; T6K21.150; T6K21_150
NCBI Protein Information
aluminum-activated, malate transporter 12
NCBI Summary
Anion transporter involved in stomatal closure. Gene has 3 splicing variants.
UniProt Synonym Gene Names
QUAC1; AtALMT12
UniProt Protein Name
Aluminum-activated malate transporter 12
UniProt Synonym Protein Names
Quick anion channel 1
UniProt Entry Name
ALMTC_ARATH
UniProt Primary Accession #
O49696
UniProt Related Accession #
T05083
UniProt Comments
Function: Malate-sensitive anion transporter permeable to chloride, nitrate, sulfate and malate. Involved in dark-, CO(2)-, abscisic acid- and water-deficient-induced stomatal closure. Belongs to the R-type anion channels.Subcellular location: Cell membrane; Multi-pass membrane protein. Note: indicates also a not confirmed endomembrane localization.Tissue specificity: Expressed in roots, stems, leaves, flowers and pollen. Mainly detected in the roots vascular stele and in the leaves guard cells.Induction: Not induced by aluminum.Disruption phenotype: Impaired stomatal closure resulting in a wilty phenotype.Miscellaneous: Malate functions as a gating modifier as well as a permeating substrate.Sequence similarities: Belongs to the aromatic acid exporter (TC 2.A.85) family.