NCBI Accession #
NP_201226.2
NCBI GenBank Nucleotide #
NM_125817.2
NCBI Official Full Name
alternative oxidase 2
NCBI Official Symbol
AOX2
NCBI Official Synonym Symbols
ALTERNATIVE OXIDASE; alternative oxidase 2; AOX2; MSJ1.5; MSJ1_5
NCBI Protein Information
alternative oxidase 2
UniProt Protein Name
Ubiquinol oxidase 2, mitochondrial
UniProt Synonym Protein Names
Alternative oxidase 2
UniProt Entry Name
AOX2_ARATH
UniProt Primary Accession #
O22049
UniProt Secondary Accession #
Q4PS98
UniProt Related Accession #
O22049
UniProt Comments
Function: Catalyzes the cyanide-resistant oxidation of ubiquinol and the reduction of molecular oxygen to water, but does not translocate protons and consequently is not linked to oxidative phosphorylation. May increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures By similarity.Catalytic activity: 2 ubiquinol + O2 = 2 ubiquinone + 2 H2O.Cofactor: Binds 2 iron ions per subunit.Subunit structure: Homodimer; disulfide-linked Probable.Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein. Note: Mitochondrial, possibly in the inner surface of the inner mitochondrial membrane.Tissue specificity: Maximally expressed in dry seeds. Detected in roots, stems and leaves.Developmental stage: Expressed predominantly during early stages of germination with maximum level at 12 hours after imbibition and at the latter stages of silique maturation. Accumulates in dry seeds.Induction: No effect of antimycin A, ethylene or cold treatments. Up-regulated by paraquat and cystein treatments, but down-regulated by erythromycin, citrate, glucose and H2O2 treatments.Sequence similarities: Belongs to the alternative oxidase family.Sequence caution: The sequence BAB09852.1 differs from that shown. Reason: Erroneous gene model prediction.