NCBI Accession #
NP_199207.1
NCBI GenBank Nucleotide #
NM_123761.4
NCBI Official Full Name
GroES-like zinc-binding dehydrogenase family protein
NCBI Official Symbol
HOT5
NCBI Official Synonym Symbols
ADH2; ALCOHOL DEHYDROGENASE 2; ATGSNOR1; FALDH; GLUTATHIONE-DEPENDENT FORMALDEHYDE DEHYDROGENASE; GSNOR; MRH10.4; MRH10_4; PAR2; PARAQUAT RESISTANT 2; S-NITROSOGLUTATHIONE REDUCTASE; sensitive to hot temperatures 5
NCBI Protein Information
GroES-like zinc-binding dehydrogenase family protein
NCBI Summary
Encodes a glutathione-dependent formaldehyde dehydrogenase (also known as class III type alcohol dehydrogenase) reduces S-nitrosoglutathione (GSNO), the condensation product of glutathione and NO, that is a naturally occurring NO reservoir and also a reactive nitrogen intermediate. Gene expression is reduced by wounding and induced by salicylic acid. Is required for the acclimation of plants to high temperature and for fertility.
UniProt Synonym Gene Names
ADHIII; FDH1; FALDH; FDH; GSH-FDH
UniProt Protein Name
Alcohol dehydrogenase class-3
UniProt Synonym Protein Names
Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase (EC:1.1.1.-); FALDH; FDH; GSH-FDH; S-(hydroxymethyl)glutathione dehydrogenase (EC:1.1.1.284
UniProt Primary Accession #
Q96533
UniProt Secondary Accession #
Q0WWE1; Q43384; Q9FND2
UniProt Related Accession #
Q96533
UniProt Comments
Plays a central role in formaldehyde detoxification.